Gross and histological types of early gastric carcinomas in relation to the acid-secreting area.

The relation of gastric acid-secreting function to the gross and histological types and locations of carcinomas was examined in 53 patients with early gastric carcinomas. Studies were made by the endoscopic Congo red test developed in this clinic. Results indicated a close correlation between the gross and histological types of early gastric carcinoma and the extent of the acid-secreting area. In general, when the acid-secreting area was large, the carcinomas were ulcerated and histologically undifferentiated and they were chiefly located in nonacid-secreting areas adjacent to acid-secreting areas, or sometimes they were surrounded by acid-secreting areas. On the contrary, when there was little or no acid-secreting area the carcinomas were polyploid and histologically differentiated, and they were located in nonacid-secreting areas far from acid-secreting areas.