PURPOSE: To detect whether untreated primary open-angle glaucoma or ocular hypertension is associated with an impaired basal tear turnover. METHODS: Basal tear turnover was determined by fluorophotometry in 18 patients with newly detected, untreated primary open-angle glaucoma and 29 patients with untreated ocular hypertension. The results were compared with those of 27 age-matched control subjects. RESULTS: The basal tear turnover in glaucoma patients (mean +/- S.D., 11.4 +/- 3.1%/min) was 22% lower than in patients with ocular hypertension (14.7 +/- 3.0%/min; P = .0007) and 27% lower than in control subjects (15.7 +/- 5.3%/min; P = .001). Tear turnover of patients with ocular hypertension did not differ significantly from that of control subjects (P = .4). The basal tear turnover values were found to decrease with increasing vertical or horizontal cup/disk ratios (P = .004 and P = .008, respectively). CONCLUSIONS: Primary open-angle glaucoma, but not ocular hypertension, was found to be associated with an impaired basal tear turnover. Dry eye complaints may originate from decreased basal tear turnover as a result of glaucoma drug therapy as well as from primary open-angle glaucoma itself.
PURPOSE: To detect whether untreated primary open-angle glaucoma or ocular hypertension is associated with an impaired basal tear turnover. METHODS: Basal tear turnover was determined by fluorophotometry in 18 patients with newly detected, untreated primary open-angle glaucoma and 29 patients with untreated ocular hypertension. The results were compared with those of 27 age-matched control subjects. RESULTS: The basal tear turnover in glaucomapatients (mean +/- S.D., 11.4 +/- 3.1%/min) was 22% lower than in patients with ocular hypertension (14.7 +/- 3.0%/min; P = .0007) and 27% lower than in control subjects (15.7 +/- 5.3%/min; P = .001). Tear turnover of patients with ocular hypertension did not differ significantly from that of control subjects (P = .4). The basal tear turnover values were found to decrease with increasing vertical or horizontal cup/disk ratios (P = .004 and P = .008, respectively). CONCLUSIONS: Primary open-angle glaucoma, but not ocular hypertension, was found to be associated with an impaired basal tear turnover. Dry eye complaints may originate from decreased basal tear turnover as a result of glaucoma drug therapy as well as from primary open-angle glaucoma itself.
Authors: Mark D P Willcox; Pablo Argüeso; Georgi A Georgiev; Juha M Holopainen; Gordon W Laurie; Tom J Millar; Eric B Papas; Jannick P Rolland; Tannin A Schmidt; Ulrike Stahl; Tatiana Suarez; Lakshman N Subbaraman; Omür Ö Uçakhan; Lyndon Jones Journal: Ocul Surf Date: 2017-07-20 Impact factor: 5.033
Authors: L M van Beek; R J de Keizer; B C Polak; P R Elzenaar; N J van Haeringen; A Kijlstra Journal: Br J Ophthalmol Date: 2000-08 Impact factor: 4.638