Literature DB >> 7610992

Recent insights into the structure, function and biology of cPLA2.

R M Kramer1, J D Sharp.   

Abstract

The 85-kDa cytosolic PLA2 (cPLA2) is present in most cells and tissues and its structural and functional properties have been described. Different agonists, growth factors and cytokines activate cPLA2 to hydrolyze cellular phospholipids thereby providing the precursor substrates for the biosynthesis of eicosanoids and platelet-activating factor (PAF), the well-known mediators of inflammatory and allergic reactions. Recent studies discussed here suggest that cPLA2 is a receptor-regulated enzyme involved in the inflammatory response. Therefore, inhibitors of cPLA2 may be useful as therapeutic agents in the treatment of inflammatory diseases.

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Year:  1995        PMID： 7610992     DOI： 10.1007/978-3-0348-7276-8_7

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN： 0379-0363


  11 in total

1.  Dual role of protein kinase C in the regulation of cPLA2-mediated arachidonic acid release by P2U receptors in MDCK-D1 cells: involvement of MAP kinase-dependent and -independent pathways.

Authors:  M Xing; B L Firestein; G H Shen; P A Insel
Journal:  J Clin Invest       Date:  1997-02-15       Impact factor: 14.808

2.  Shiga toxin 2 and lipopolysaccharide induce human microvascular endothelial cells to release chemokines and factors that stimulate platelet function.

Authors:  Fadila Guessous; Marek Marcinkiewicz; Renata Polanowska-Grabowska; Sudawadee Kongkhum; Daniel Heatherly; Tom Obrig; Adrian R L Gear
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

3.  Phospholipase A2 isoforms are altered in chronic pancreatitis.

Authors:  M Kashiwagi; H Friess; W Uhl; H Graber; R Duarte; A Zimmermann; M W Büchler
Journal:  Ann Surg       Date:  1998-02       Impact factor: 12.969

4.  Group II and IV phospholipase A(2) are produced in human pancreatic cancer cells and influence prognosis.

Authors:  M Kashiwagi; H Friess; W Uhl; P Berberat; M Abou-Shady; M Martignoni; S E Anghelacopoulos; A Zimmermann; M W Büchler
Journal:  Gut       Date:  1999-10       Impact factor: 23.059

5.  Host cell phospholipids are trafficked to and then modified by Chlamydia trachomatis.

Authors:  J L Wylie; G M Hatch; G McClarty
Journal:  J Bacteriol       Date:  1997-12       Impact factor: 3.490

6.  Phospholipase A2 isoforms in acute pancreatitis.

Authors:  H Friess; S Shrikhande; E Riesle; M Kashiwagi; K Baczako; A Zimmermann; W Uhl; M W Büchler
Journal:  Ann Surg       Date:  2001-02       Impact factor: 12.969

7.  Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry.

Authors:  Yuan-Hao Hsu; John E Burke; Daren L Stephens; Raymond A Deems; Sheng Li; Kyle M Asmus; Virgil L Woods; Edward A Dennis
Journal:  J Biol Chem       Date:  2008-01-21       Impact factor: 5.157

8.  Pentalinonsterol, a Phytosterol from Pentalinon andrieuxii, is Immunomodulatory through Phospholipase A2 in Macrophages toward its Antileishmanial Action.

Authors:  Sanjay Varikuti; Andrew B Shelton; Sainath R Kotha; Travis Gurney; Gaurav Gupta; Thomas J Hund; James R Fuchs; A Douglas Kinghorn; Nidhi Srivastava; Abhay R Satoskar; Narasimham L Parinandi
Journal:  Cell Biochem Biophys       Date:  2021-08-13       Impact factor: 2.194

9.  Mast cell chemotaxis - chemoattractants and signaling pathways.

Authors:  Ivana Halova; Lubica Draberova; Petr Draber
Journal:  Front Immunol       Date:  2012-05-25       Impact factor: 7.561

10.  Arachidonic Acid Attenuates Cell Proliferation, Migration and Viability by a Mechanism Independent on Calcium Entry.

Authors:  Carlos Cantonero; Jose Sánchez-Collado; Jose J Lopez; Ginés M Salido; Juan A Rosado; Pedro C Redondo
Journal:  Int J Mol Sci       Date:  2020-05-07       Impact factor: 5.923
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