Literature DB >> 7610497

Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

A J Hunter1, A R Green, A J Cross.   

Abstract

Substantial efforts are being made to develop drugs which will protect the brain from the neurodegeneration that follows an acute ischaemic stroke. However, while there are already a significant number of animal models of stroke, there is currently no information as to whether activity of a compound in any of them will predict clinical efficacy. In this article, Jackie Hunter, Richard Green and Alan Cross review the major models of acute cerebral ischaemia and propose rational protocols for examining novel neuroprotective agents.

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Year:  1995        PMID： 7610497     DOI： 10.1016/s0165-6147(00)88999-3

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  18 in total

Review 1.  Epileptogenesis after experimental focal cerebral ischemia.

Authors:  Heli Karhunen; Jukka Jolkkonen; Juhani Sivenius; Asla Pitkänen
Journal:  Neurochem Res       Date:  2005-12       Impact factor: 3.996

2.  Altered responsiveness of the guinea-pig isolated ileum to smooth muscle stimulants and to electrical stimulation after in situ ischemia.

Authors:  Rodolfo Rodriguez; Rosa Ventura-Martinez; Jacinto Santiago-Mejia; Maria R Avila-Costa; Teresa I Fortoul
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739

3.  On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.

Authors:  R M Nelson; A R Green; D G Lambert; A H Hainsworth
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

4.  Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.

Authors:  Simona Pegorini; Daniela Braida; Chiara Verzoni; Chiara Guerini-Rocco; Gian Giacomo Consalez; Laura Croci; Mariaelvina Sala
Journal:  Br J Pharmacol       Date:  2005-03       Impact factor: 8.739

5.  Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.

Authors:  Simona Pegorini; Alessia Zani; Daniela Braida; Chiara Guerini-Rocco; Mariaelvina Sala
Journal:  Br J Pharmacol       Date:  2006-03       Impact factor: 8.739

6.  Transient global brain ischemia in the rat: spatial distribution, extension, and evolution of lesions evaluated by magnetic resonance imaging.

Authors:  R Canese; F Podo; S Fortuna; P Lorenzini; H Michalek
Journal:  MAGMA       Date:  1997-06       Impact factor: 2.310

7.  Association between changes in weight and cerebral arteries in rats.

Authors:  Afshin A Divani; Ankur Patel; Vance L Fredrickson; Blake Siljander; Gabriela Vazquez
Journal:  Transl Stroke Res       Date:  2010-03-02       Impact factor: 6.829

8.  Animal models of focal brain ischemia.

Authors:  Kenneth M Sicard; Marc Fisher
Journal:  Exp Transl Stroke Med       Date:  2009-11-13

9.  Preclinical stroke research: gains and gaps.

Authors:  David A Greenberg
Journal:  Stroke       Date:  2013-06       Impact factor: 7.914

10.  Delta9-tetrahydrocannabinol (THC) and AM 404 protect against cerebral ischaemia in gerbils through a mechanism involving cannabinoid and opioid receptors.

Authors:  A Zani; D Braida; V Capurro; M Sala
Journal:  Br J Pharmacol       Date:  2007-10-29       Impact factor: 8.739
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