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Literature DB >> 7610481

The dynamic role of palmitoylation in signal transduction.

Abstract

Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.

Entities: Chemical

Mesh：

Substances：
Palmitates

Year: 1995 PMID： 7610481 DOI： 10.1016/s0968-0004(00)89004-0

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

80 in total

1. Functional roles for fatty acylated amino-terminal domains in subcellular localization.

Authors: J B McCabe; L G Berthiaume
Journal: Mol Biol Cell Date: 1999-11 Impact factor: 4.138

Review 2. Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.

Authors: H LeVine
Journal: Mol Neurobiol Date: 1999-04 Impact factor: 5.590

3. Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.

Authors: S Arnould; M Takahashi; J M Camadro
Journal: Proc Natl Acad Sci U S A Date: 1999-12-21 Impact factor: 11.205

4. An Arabidopsis calcium-dependent protein kinase is associated with the endoplasmic reticulum.

Authors: Sheen X Lu; Estelle M Hrabak
Journal: Plant Physiol Date: 2002-03 Impact factor: 8.340

5. Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.

Authors: Shoji X Takahashi; Scott Mittman; Henry M Colecraft
Journal: Biophys J Date: 2003-05 Impact factor: 4.033

10. Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with Gα(o) in neuroblastoma NB-2a cells.

Authors: Karolina Tułodziecka; Magdalena Czeredys; Katarzyna A Nałęcz
Journal: Neurochem Res Date: 2012-12-09 Impact factor: 3.996

The dynamic role of palmitoylation in signal transduction.

1. Functional roles for fatty acylated amino-terminal domains in subcellular localization.

Review 2. Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins.

3. Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.

4. An Arabidopsis calcium-dependent protein kinase is associated with the endoplasmic reticulum.

5. Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.

6. Autopalmitoylation of tubulin.

7. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.

8. DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.

Review 9. Membrane organization and function of the serotonin(1A) receptor.

10. Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with Gα(o) in neuroblastoma NB-2a cells.