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Literature DB >> 7610476

Are the 'core' proteins of the mitochondrial bc1 complex evolutionary relics of a processing protease?

Abstract

The so-called 'core' proteins of the respiratory cytochrome bc1 complex and the two subunits of the mitochondrial processing peptidase (MPP) are structurally similar but their evolutionary relationship remains a mystery. Here, we present a model suggesting that the core proteins originated from an ancient proteolytic enzyme that was integrated into the bc1 complex during early stages of endosymbiosis.

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Year: 1995 PMID： 7610476 DOI： 10.1016/s0968-0004(00)88999-9

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

28 in total

1. Thermolysin and mitochondrial processing peptidase: how far structure-functional convergence goes.

Authors: K S Makarova; N V Grishin
Journal: Protein Sci Date: 1999-11 Impact factor: 6.725

2. Characterization and submitochondrial localization of the alpha subunit of the mitochondrial processing peptidase from the aquatic fungus Blastocladiella emersonii.

Authors: C R Rocha; S L Gomes
Journal: J Bacteriol Date: 1999-07 Impact factor: 3.490

3. Higher plant mitochondria

Authors:
Journal: Plant Cell Date: 1999-04 Impact factor: 11.277

4. Purification and characterization of the preprotein translocase of the outer mitochondrial membrane from Arabidopsis. Identification of multiple forms of TOM20.

Authors: W Werhahn; A Niemeyer; L Jänsch; V Kruft; U K Schmitz; H Braun
Journal: Plant Physiol Date: 2001-02 Impact factor: 8.340

5. A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction.

Authors: Ryan Lister; Orinda Chew; May-Nee Lee; Joshua L Heazlewood; Rachel Clifton; Karen L Parker; A Harvey Millar; James Whelan
Journal: Plant Physiol Date: 2004-01-15 Impact factor: 8.340

Are the 'core' proteins of the mitochondrial bc1 complex evolutionary relics of a processing protease?

1. Thermolysin and mitochondrial processing peptidase: how far structure-functional convergence goes.

2. Characterization and submitochondrial localization of the alpha subunit of the mitochondrial processing peptidase from the aquatic fungus Blastocladiella emersonii.

3. Higher plant mitochondria

4. Purification and characterization of the preprotein translocase of the outer mitochondrial membrane from Arabidopsis. Identification of multiple forms of TOM20.

5. A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction.

6. Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p.

7. Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III.

8. Using synthetic biology to overcome barriers to stable expression of nitrogenase in eukaryotic organelles.

Review 9. Mitochondrial protein import in plants. Signals, sorting, targeting, processing and regulation.

10. Structure and mechanism of the saposin-like domain of a plant aspartic protease.