Literature DB >> 7609638

The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system.

C Kurschner1, J I Morgan.   

Abstract

Bcl-2 can rescue neurons from death and might, therefore, exert its action by associating with neuron-specific proteins. Using LexA-Bcl-2 as bait, we find that the cellular prion protein (PrP) interacts with Bcl-2, but not Bax, in the yeast two-hybrid system. Since the PrP gene has been implicated in neurodegenerative disorders, this preliminary observation suggests a potential pathogenic mechanism for these conditions.

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Year:  1995        PMID： 7609638     DOI： 10.1016/0169-328x(95)00013-i

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  30 in total

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5.  The prion protein gene is dispensable for the development of spongiform myeloencephalopathy induced by the neurovirulent Cas-Br-E murine leukemia virus.

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8.  Cell type-specific neuroprotective activity of untranslocated prion protein.

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Review 9.  The cellular prion protein (PrP(C)): its physiological function and role in disease.

Authors:  Laura Westergard; Heather M Christensen; David A Harris
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10.  Prion and doppel proteins bind to granule cells of the cerebellum.

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