PURPOSE: Vascular permeability factor (VPF) is a potent inducer of microvascular hyperpermeability and stimulates endothelial cell growth and angiogenesis. This study examines expression of VPF in the male genital tract. MATERIALS AND METHODS: Vascular permeability factor in seminal plasma was quantified by immunoassay. Vascular permeability factor mRNA and protein expression in tissue were studied by situ hybridization and immunohistochemistry. RESULTS: All seminal plasmas studied contained high levels of VPF. Prostatic and seminal vesicle epithelium labeled strongly for VPF mRNA and protein. CONCLUSIONS: The strong expression of VPF in prostate and seminal vesicle and the high concentration of VPF in semen suggest an important role for this cytokine in male fertility.
PURPOSE:Vascular permeability factor (VPF) is a potent inducer of microvascular hyperpermeability and stimulates endothelial cell growth and angiogenesis. This study examines expression of VPF in the male genital tract. MATERIALS AND METHODS:Vascular permeability factor in seminal plasma was quantified by immunoassay. Vascular permeability factor mRNA and protein expression in tissue were studied by situ hybridization and immunohistochemistry. RESULTS: All seminal plasmas studied contained high levels of VPF. Prostatic and seminal vesicle epithelium labeled strongly for VPF mRNA and protein. CONCLUSIONS: The strong expression of VPF in prostate and seminal vesicle and the high concentration of VPF in semen suggest an important role for this cytokine in male fertility.
Authors: Przemyslaw Solek; Jennifer Mytych; Ewelina Sujkowska; Magdalena Grzegorczyk; Patrycja Jasiewicz; Magdalena Sowa-Kucma; Katarzyna Stachowicz; Marek Koziorowski; Anna Tabecka-Lonczynska Journal: Toxicol Res Date: 2021-05-20
Authors: E I Korpelainen; M J Karkkainen; A Tenhunen; M Lakso; H Rauvala; M Vierula; M Parvinen; K Alitalo Journal: J Cell Biol Date: 1998-12-14 Impact factor: 10.539