Literature DB >> 7608819

Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis.

M Muñoz1, E S Valderrabanos, E Diaz, J J Silva, J A Soult, P Infante, J D Lopez, A Garcia-Curiel.   

Abstract

A young boy had meningitis caused by Streptococcus pneumoniae that was relatively resistant to penicillin and susceptible to cefotaxime. After 10 days of therapy with penicillin and cefotaxime, fever recurred and a second lumbar puncture revealed a pneumococcus that was resistant to all beta-lactam antibiotics. We now add vancomycin to empiric third-generation cephalosporin therapy for meningitis in children when gram-positive cocci are seen on the cerebrospinal fluid smear.

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Year:  1995        PMID: 7608819     DOI: 10.1016/s0022-3476(95)70264-4

Source DB:  PubMed          Journal:  J Pediatr        ISSN: 0022-3476            Impact factor:   4.406


  3 in total

1.  The emergence of resistant pneumococcal meningitis--implications for empiric therapy.

Authors:  P McMaster; P McIntyre; R Gilmour; L Gilbert; A Kakakios; C Mellis
Journal:  Arch Dis Child       Date:  2002-09       Impact factor: 3.791

2.  Synergistic activity of trovafloxacin and ceftriaxone or vancomycin against Streptococcus pneumoniae with various penicillin susceptibilities.

Authors:  D P Nicolau; P R Tessier; R Quintiliani; C H Nightingale
Journal:  Antimicrob Agents Chemother       Date:  1998-04       Impact factor: 5.191

Review 3.  Management of infections due to antibiotic-resistant Streptococcus pneumoniae.

Authors:  S L Kaplan; E O Mason
Journal:  Clin Microbiol Rev       Date:  1998-10       Impact factor: 26.132

  3 in total

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