| Literature DB >> 7608321 |
A F Benslimane1, Y F Pouchus, J F Verbist, J Y Petit, J D Brion, L Welin.
Abstract
The mechanism of antiinflammatory action of cordiachromene A, isolated from the chloromethylenic extract of the ascidian Aplidium antillense or chemically synthesized, was studied using different in vivo and in vitro inhibition tests on enzymes of the cyclooxygenase cascade. Cordiachromene A inhibits prostacyclin synthesis and arachidonic acid metabolism but not phospholipase A2 and peroxidase. The mechanism of action, already known to be stereospecific, operates by cyclooxygenase inhibition.Entities:
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Year: 1995 PMID： 7608321 DOI： 10.1002/j.1552-4604.1995.tb04063.x
Source DB: PubMed Journal: J Clin Pharmacol ISSN： 0091-2700 Impact factor: 3.126