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Literature DB >> 7607686

Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.

K L Puranam¹, E Kennington, S N Sait, T B Shows, J M Rochelle, M F Seldin, P J Blackshear.

Abstract

We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ. RECQL was localized to human chromosome 12 by analysis of human-rodent somatic cell hybrid DNA; fine mapping of RECQL by fluorescence in situ hybridization revealed its chromosomal location to be 12p11-p12. The corresponding mouse gene, Recql, was mapped to the telomeric end of mouse chromosome 6 by analysis of DNA from an interspecific cross.

Entities: Gene Species

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Year: 1995 PMID： 7607686 DOI： 10.1016/0888-7543(95)80181-k

Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736

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Cited

11 in total

1. Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein.

Authors: Kristina H Schmidt; Joann Wu; Richard D Kolodner
Journal: Mol Cell Biol Date: 2006-07 Impact factor: 4.272

10. Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.

Authors: Sudha Sharma; Robert M Brosh
Journal: PLoS One Date: 2007-12-12 Impact factor: 3.240

Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.

1. Control of translocations between highly diverged genes by Sgs1, the Saccharomyces cerevisiae homolog of the Bloom's syndrome protein.

2. RECQ1 plays a distinct role in cellular response to oxidative DNA damage.

3. The essential role of yeast topoisomerase III in meiosis depends on recombination.

4. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.

5. Genome-wide investigations on regulatory functions of RECQ1 helicase.

6. Unique and important consequences of RECQ1 deficiency in mammalian cells.

7. Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.

Review 8. RecQ helicases: suppressors of tumorigenesis and premature aging.

Review 9. Probing Genome Maintenance Functions of human RECQ1.

10. Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.