Literature DB >> 7607664

Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13.

J Zhou1, J L Neidigh, R Espinosa, M M LeBeau, D A McClain.   

Abstract

It has been previously shown that some toxic effects of high concentrations of glucose are mediated by the hexosamine biosynthesis pathway and its rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA). We have used the cloned human GFA cDNA to study the chromosomal localization of the gene and tissue distribution of mRNA. The human GFA gene is on chromosome 2, band p13 as determined by fluorescence in situ hybridization. An 8-kb species of GFA mRNA was detected in all rat tissues tested with relatively high expression in testis and smooth muscle; a unique 3-kb mRNA species was found only in testis.

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Year:  1995        PMID： 7607664     DOI： 10.1007/BF00214194

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

1.  Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.

Authors:  J D Rowley; M O Diaz; R Espinosa; Y D Patel; E van Melle; S Ziemin; P Taillon-Miller; P Lichter; G A Evans; J H Kersey
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Fructose transporter in human spermatozoa and small intestine is GLUT5.

Authors:  C F Burant; J Takeda; E Brot-Laroche; G I Bell; N O Davidson
Journal:  J Biol Chem       Date:  1992-07-25       Impact factor: 5.157

3.  Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

Authors:  S Marshall; V Bacote; R R Traxinger
Journal:  J Biol Chem       Date:  1991-03-15       Impact factor: 5.157

4.  Glucose regulation of transforming growth factor-alpha expression is mediated by products of the hexosamine biosynthesis pathway.

Authors:  M C Daniels; P Kansal; T M Smith; A J Paterson; J E Kudlow; D A McClain
Journal:  Mol Endocrinol       Date:  1993-08

5.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

Authors:  D M Nathan; S Genuth; J Lachin; P Cleary; O Crofford; M Davis; L Rand; C Siebert
Journal:  N Engl J Med       Date:  1993-09-30       Impact factor: 91.245

6.  Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts.

Authors:  E D Crook; M C Daniels; T M Smith; D A McClain
Journal:  Diabetes       Date:  1993-09       Impact factor: 9.461

7.  Molecular cloning, cDNA sequence, and bacterial expression of human glutamine:fructose-6-phosphate amidotransferase.

Authors:  G L McKnight; S L Mudri; S L Mathewes; R R Traxinger; S Marshall; P O Sheppard; P J O'Hara
Journal:  J Biol Chem       Date:  1992-12-15       Impact factor: 5.157

8.  Glucose and glucosamine regulate growth factor gene expression in vascular smooth muscle cells.

Authors:  D A McClain; A J Paterson; M D Roos; X Wei; J E Kudlow
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205
  8 in total
  6 in total

1.  Molecular characterization, chromosomal location, alternative splicing and polymorphism of porcine GFAT1 gene.

Authors:  K Liu; G Wang; S H Zhao; B Liu; J N Huang; X Bai; M Yu
Journal:  Mol Biol Rep       Date:  2009-09-13       Impact factor: 2.316

2.  Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

Authors:  L F Hebert; M C Daniels; J Zhou; E D Crook; R L Turner; S T Simmons; J L Neidigh; J S Zhu; A D Baron; D A McClain
Journal:  J Clin Invest       Date:  1996-08-15       Impact factor: 14.808

Review 3.  Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars.

Authors:  Brenna M Zimmer; Joseph J Barycki; Melanie A Simpson
Journal:  Am J Physiol Cell Physiol       Date:  2022-04-20       Impact factor: 5.282

4.  Glutamine:fructose-6-phosphate amidotransferase activity in cultured human skeletal muscle cells: relationship to glucose disposal rate in control and non-insulin-dependent diabetes mellitus subjects and regulation by glucose and insulin.

Authors:  M C Daniels; T P Ciaraldi; S Nikoulina; R R Henry; D A McClain
Journal:  J Clin Invest       Date:  1996-03-01       Impact factor: 14.808

5.  High expression of GFAT1 predicts unfavorable prognosis in patients with hepatocellular carcinoma.

Authors:  Lili Li; Miaomiao Shao; Peike Peng; Caiting Yang; Shushu Song; Fangfang Duan; Dongwei Jia; Mingming Zhang; Junjie Zhao; Ran Zhao; Weicheng Wu; Lan Wang; Can Li; Hao Wu; Jie Zhang; Xin Wu; Yuanyuan Ruan; Jianxin Gu
Journal:  Oncotarget       Date:  2017-03-21

Review 6.  Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants.

Authors:  Siba Shanak; Bashar Saad; Hilal Zaid
Journal:  Evid Based Complement Alternat Med       Date:  2019-05-05       Impact factor: 2.629
  6 in total

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