Literature DB >> 7607303

Taxuspine D, a new taxane diterpene from Taxus cuspidata with potent inhibitory activity against Ca(2+)-induced depolymerization of microtubules.

J Kobayashi1, H Hosoyama, H Shigemori, Y Koiso, S Iwasaki.   

Abstract

A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca(2+)-induced depolymerization of microtubules.

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Year:  1995        PMID： 7607303     DOI： 10.1007/BF02128750

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

Review 1.  The chemistry of taxol.

Authors:  D G Kingston
Journal:  Pharmacol Ther       Date:  1991-10       Impact factor: 12.310

2.  Taxinine M, a new tetracyclic taxane from Taxus brevifolia.

Authors:  J A Beutler; G M Chmurny; S A Look; K M Witherup
Journal:  J Nat Prod       Date:  1991 May-Jun       Impact factor: 4.050

3.  Microtubule assembly in the absence of added nucleotides.

Authors:  M L Shelanski; F Gaskin; C R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

Review 4.  The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics.

Authors:  E K Rowinsky; R C Donehower
Journal:  Pharmacol Ther       Date:  1991-10       Impact factor: 12.310

5.  Promotion of microtubule assembly in vitro by taxol.

Authors:  P B Schiff; J Fant; S B Horwitz
Journal:  Nature       Date:  1979-02-22       Impact factor: 49.962
  5 in total
  1 in total

Review 1.  Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.

Authors:  B Markus Lange; Caleb F Conner
Journal:  Phytochemistry       Date:  2021-07-27       Impact factor: 4.004
  1 in total

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