Literature DB >> 7606924

Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death.

T Kawakami1, Y Furukawa, K Sudo, H Saito, S Takami, E Takahashi, Y Nakamura.   

Abstract

From a human fetal lung cDNA library we isolated and characterized a human cDNA highly homologous to Rp8, a rat gene associated with programmed cell death. This cDNA, termed PDCD2 (programmed cell death-2), contained an open reading frame of 1032 nucleotides encoding 344 amino acids; it revealed 81% identity in DNA sequence and 83% identity in amino acid sequence with rat Rp8. The gene represented by PDCD2 was expressed in all human tissues examined. We assigned the PDCD2 locus to chromosomal band 6q27 by fluorescence in situ hybridization (FISH).

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Year:  1995        PMID： 7606924     DOI： 10.1159/000134058

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  11 in total

1.  Growth arrest-inducing genes are activated in Dbl-transformed mouse fibroblasts.

Authors:  Raffaella Melani; Fabio Sallustio; Paolo Fardin; Cristina Vanni; Marzia Ognibene; Catherine Ottaviano; Giovanni Melillo; Luigi Varesio; Alessandra Eva
Journal:  Gene Expr       Date:  2006

2.  PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.

Authors:  Weipeng Mu; Robert J Munroe; Anna K Barker; John C Schimenti
Journal:  Dev Biol       Date:  2010-09-09       Impact factor: 3.582

3.  The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis.

Authors:  Beverly W Baron; John Anastasi; Michael J Thirman; Yoichi Furukawa; Scott Fears; David C Kim; Federico Simone; Mark Birkenbach; Anthony Montag; Annamma Sadhu; Nancy Zeleznik-Le; Timothy W McKeithan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

4.  Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.

Authors:  Yuanxun Yang; Yan Jin; Wenxi Du
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

5.  Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.

Authors:  Beverly W Baron; Nancy Zeleznik-Le; Miriam J Baron; Catherine Theisler; Dezheng Huo; Matthew D Krasowski; Michael J Thirman; Rebecca M Baron; Joseph M Baron
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-27       Impact factor: 11.205

6.  PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.

Authors:  Natalia A Kokorina; Celine J Granier; Stanislav O Zakharkin; Stephani Davis; Arnold B Rabson; Hatem E Sabaawy
Journal:  Exp Hematol       Date:  2012-08-22       Impact factor: 3.084

7.  PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.

Authors:  Nora Barboza; Svetlana Minakhina; Daniel J Medina; Binaifer Balsara; Sonya Greenwood; Lien Huzzy; Arnold B Rabson; Ruth Steward; Dale G Schaar
Journal:  Cancer Biol Ther       Date:  2013-06       Impact factor: 4.742

8.  Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest.

Authors:  Celine J Granier; Wei Wang; Tiffany Tsang; Ruth Steward; Hatem E Sabaawy; Mantu Bhaumik; Arnold B Rabson
Journal:  Biol Open       Date:  2014-08-22       Impact factor: 2.422

9.  The Molecular Evolution and Functional Divergence of Lamprey Programmed Cell Death Genes.

Authors:  Xin Guan; Jiali Lu; Feng Sun; Qingwei Li; Yue Pang
Journal:  Front Immunol       Date:  2019-06-20       Impact factor: 7.561

10.  Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.

Authors:  A P Sutter; K Maaser; B Barthel; H Scherübl
Journal:  Br J Cancer       Date:  2003-08-04       Impact factor: 7.640
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