| Literature DB >> 7606464 |
R M Bluthé1, C Beaudu, K W Kelley, R Dantzer.
Abstract
Peripheral and central injections of recombinant human interleukin-1 beta (IL-1 beta) have been shown to decrease social exploration and to induce body weight loss in rats. To characterize the receptor mechanisms of these effects, we used as a tool a specific antagonist of the receptors of IL-1, IL-1ra. Intraperitoneal (i.p.) administration of IL-1ra (8 mg/kg) blocked the effect of i.p. injection of IL-1 beta (4 micrograms/rat) on social behaviour but not on body weight. Central administration of IL-1ra (60 micrograms/rat, i.c.v.) abrogated the effects of centrally administered IL-1 beta (30 ng/rat, i.c.v.) on both social behaviour and body weight. Central injection of IL-1ra (4 micrograms/rat, i.c.v.) also attenuated the effects of i.p. administered IL-1 beta (4 micrograms/rat) on social behaviour but not on body weight. These results suggest that the effects of IL-1 beta on social behavior are mediated centrally and that its effect on the loss of body weight involves different receptor mechanisms.Entities:
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Year: 1995 PMID： 7606464 DOI： 10.1016/0006-8993(95)00194-u
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252