Literature DB >> 7606336

Coronary vasoconstriction in vitro in the hearts of polyarthritic rats: effectiveness of in vivo treatment with the endothelin receptor antagonist SB 209670.

P Klemm1, T D Warner, D Willis, A R Moore, J R Vane.   

Abstract

Here we demonstrate that perfused hearts removed from polyarthritic rats develop a pronounced coronary vasoconstriction ex vivo. This vasoconstriction is almost entirely blocked by in vivo pretreatment of the rats with the endothelin receptor antagonist, SB 209670. Thus, inflammatory states may be associated with an increased activity of the endothelin system, leading to vascular dysfunction and vasoconstriction.

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Year:  1995        PMID： 7606336      PMCID： PMC1510275          DOI： 10.1111/j.1476-5381.1995.tb13351.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

Review 1.  Cytokines: coordinators of immune and inflammatory responses.

Authors:  K I Arai; F Lee; A Miyajima; S Miyatake; N Arai; T Yokota
Journal:  Annu Rev Biochem       Date:  1990       Impact factor: 23.643

2.  Cytokine stimulated endothelin release from endothelial cells.

Authors:  S M Kanse; K Takahashi; H C Lam; A Rees; J B Warren; M Porta; P Molinatti; M Ghatei; S R Bloom
Journal:  Life Sci       Date:  1991       Impact factor: 5.037

3.  Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells.

Authors:  T L Yue; X Wang; C P Sung; B Olson; P J McKenna; J L Gu; G Z Feuerstein
Journal:  Circ Res       Date:  1994-07       Impact factor: 17.367

Review 4.  Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis.

Authors:  W P Arend; J M Dayer
Journal:  Arthritis Rheum       Date:  1990-03

5.  Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage, cytokines and hypoxia in rats.

Authors:  S Vemulapalli; P J Chiu; K Griscti; A Brown; S Kurowski; E J Sybertz
Journal:  Eur J Pharmacol       Date:  1994-05-12       Impact factor: 4.432

6.  Changes in hepatic mRNA levels of acute phase proteins during rat adjuvant arthritis.

Authors:  T Geiger; M Fischer; B Jagher; W Pignat; B J Tscherry; I Wiesenberg
Journal:  Clin Exp Rheumatol       Date:  1992 Sep-Oct       Impact factor: 4.473

7.  SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

Authors:  E H Ohlstein; P Nambi; S A Douglas; R M Edwards; M Gellai; A Lago; J D Leber; R D Cousins; A Gao; J S Frazee
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-16       Impact factor: 11.205

8.  Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: immunologic, histopathologic, and other studies.

Authors:  Y H Chang; C M Pearson; C Abe
Journal:  Arthritis Rheum       Date:  1980-01

9.  Release of endothelin in relation to tumor necrosis factor-alpha in porcine Pseudomonas aeruginosa-induced septic shock.

Authors:  J J Han; A Windsor; D H Drenning; S Leeper-Woodford; P G Mullen; D E Bechard; H J Sugerman; A A Fowler
Journal:  Shock       Date:  1994-05       Impact factor: 3.454
  9 in total
  2 in total

1.  What turns on the endothelins?

Authors:  T D Warner; P Klemm
Journal:  Inflamm Res       Date:  1996-02       Impact factor: 4.575

2.  The contribution of tumour necrosis factor-alpha and endothelin-1 to the increase of coronary resistance in hearts from rats treated with endotoxin.

Authors:  T Hohlfeld; P Klemm; C Thiemermann; T D Warner; K Schrör; J R Vane
Journal:  Br J Pharmacol       Date:  1995-12       Impact factor: 8.739
  2 in total

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