Literature DB >> 760541

The resistance of spontaneous mouse hepatocellular neoplasms to iron accumulation during rapid iron loading by parenteral administration and their transplantability.

G M Williams, N Hirota, J M Rice.   

Abstract

Spontaneous mouse liver nodules were found to be resistant to iron accumulation induced either by dietary overload or by a rapid protocol of subcutaneous injection of iron dextran. Transplants of 11 liver nodules into the mammary fat pad gave rise to neoplastic growth. Transplants of the less differentiated nodules grew more frequently and rapidly than better differentiated nodules and produced pulmonary metastases. Therefore, these mouse liver nodules are considered to be neoplasms, and their resistance to iron accumulation suggests that this marker will be useful in studying their histogenesis.

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Year:  1979        PMID： 760541      PMCID： PMC2042232     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  14 in total

1.  Transplantation of spontaneous and induced hepatomas in inbred mice.

Authors:  H B ANDERVONT; T B DUNN
Journal:  J Natl Cancer Inst       Date:  1952-10       Impact factor: 13.506

2.  Morphology and metastatic nature of induced hepatic nodular lesions in C57BL x C3H F1 mice.

Authors:  S D Vesselinovitch; N Mihailovich; K V Rao
Journal:  Cancer Res       Date:  1978-07       Impact factor: 12.701

3.  Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad.

Authors:  G M Williams; M Klaiber; E Farber
Journal:  Am J Pathol       Date:  1977-11       Impact factor: 4.307

4.  Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.

Authors:  G M Williams; K Watanabe
Journal:  J Natl Cancer Inst       Date:  1978-07       Impact factor: 13.506

5.  The toxicology of dieldrin (HEOD). I. Long-term oral toxicity studies in mice.

Authors:  A I Walker; E Thorpe; D E Stevenson
Journal:  Food Cosmet Toxicol       Date:  1973-06

6.  Transplantability and biological behavior of mouse liver tumors induced by ethylnitrosourea.

Authors:  A P Kyriazis; S D Vesselinovitch
Journal:  Cancer Res       Date:  1973-02       Impact factor: 12.701

Review 7.  The value of the mouse in carcinogenicity testing.

Authors:  P Grasso; R F Crampton
Journal:  Food Cosmet Toxicol       Date:  1972-06

8.  Transplantation of spontaneous hepatomas in C3H mice; biological and biochemical studies.

Authors:  Y Akamatsu; F Wada; R Ikegami
Journal:  Gan       Date:  1969-04

9.  Nature of early appearing, carcinogen-induced liver lesions to iron accumulation.

Authors:  G M Williams; M Klaiber; S E Parker; E Farber
Journal:  J Natl Cancer Inst       Date:  1976-07       Impact factor: 13.506

10.  Morphologic and biologic correlation of hyperplastic and neoplastic hepatic lesions occurring "spontaneously" In C3H x Y hybrid mice.

Authors:  M D Reuber
Journal:  Br J Cancer       Date:  1971-09       Impact factor: 7.640
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  8 in total

1.  The sensitivity and heterogeneity of histochemical markers for altered foci involved in liver carcinogenesis.

Authors:  N Hirota; G M Williams
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

2.  Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure.

Authors:  T Ohmori; J M Rice; G M Williams
Journal:  Histochem J       Date:  1981-01

3.  Role of diaxial versus diequatorial hydroxyl groups in the tumorigenic activity of a benzo[a]pyrene bay-region diol epoxide.

Authors:  R L Chang; A W Wood; A H Conney; H Yagi; J M Sayer; D R Thakker; D M Jerina; W Levin
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

4.  Mutagenicity and tumorigenicity of the four enantiopure bay-region 3,4-diol-1,2-epoxide isomers of dibenz[a,h]anthracene.

Authors:  Richard L Chang; Alexander W Wood; Mou Tuan Huang; Jian Guo Xie; Xiao Xing Cui; Kenneth R Reuhl; D R Boyd; Yong Lin; Weichung Joe Shih; Suresh K Balani; Haruhiko Yagi; Donald M Jerina; Allan H Conney
Journal:  Carcinogenesis       Date:  2013-05-13       Impact factor: 4.944

5.  Hepatocarcinogenesis in the mouse. Combined morphologic-stereologic studies.

Authors:  H Koen; T D Pugh; S Goldfarb
Journal:  Am J Pathol       Date:  1983-07       Impact factor: 4.307

6.  Iron exclusion by proliferative foci and neoplastic lesions induced by 7,12-dimethylbenz(a)anthracene in the rat adrenal cortex.

Authors:  K Furuya; G M Williams
Journal:  Histochem J       Date:  1985-02

7.  Iron and neoplasia.

Authors:  E D Weinberg
Journal:  Biol Trace Elem Res       Date:  1981-03       Impact factor: 3.738

8.  Enhancing effect of ethanol on aflatoxin B1-induced hepatocarcinogenesis in male ACI/N rats.

Authors:  T Tanaka; A Nishikawa; H Iwata; Y Mori; A Hara; I Hirono; H Mori
Journal:  Jpn J Cancer Res       Date:  1989-06
  8 in total

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