| Literature DB >> 7603622 |
M Touret1, M Sallanon-Moulin, M Jouvet.
Abstract
We have studied the effect of modafinil and amphetamine, two waking drugs, on the sleep-wake cycle of Sprague-Dawley rat. Both modafinil (64 or 128 mg/kg) and amphetamine (2.5 or 5 mg/kg) cause a dose dependent increase in wakefulness. However, amphetamine wakefulness is followed by a paradoxical sleep rebound on the injection day, whereas modafinil does not produce this effect. In modafinil-treated rats, the sleep pattern on the post-injection day is similar to that of controls, while that of amphetamine-treated rats is modified.Entities:
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Year: 1995 PMID： 7603622 DOI： 10.1016/0304-3940(95)11448-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046