Literature DB >> 7601254

Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6.

C S Rosenfeld1, W B Rybka, D Weinbaum, D R Carrigan, K K Knox, D F Andrews, R K Shadduck.   

Abstract

Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

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Year:  1995        PMID： 7601254

Source DB:  PubMed          Journal:  Exp Hematol        ISSN： 0301-472X            Impact factor:   3.084


  9 in total

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Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

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Authors:  Leen De Bolle; Lieve Naesens; Erik De Clercq
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

3.  The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses.

Authors:  A Ansari; V C Emery
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

Review 4.  Challenges of T cell therapies for virus-associated diseases after hematopoietic stem cell transplantation.

Authors:  Ann M Leen; Tamara Tripic; Cliona M Rooney
Journal:  Expert Opin Biol Ther       Date:  2010-03       Impact factor: 4.388

Review 5.  Post-allogeneic hematopoietic stem cell transplantation viral reactivations and viremias: a focused review on human herpesvirus-6, BK virus and adenovirus.

Authors:  Xin Wang; Shyam A Patel; Michael Haddadin; Jan Cerny
Journal:  Ther Adv Infect Dis       Date:  2021-05-24

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Authors:  Duncan A Clark
Journal:  Int J Hematol       Date:  2002-08       Impact factor: 2.319

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Authors:  Nahed M Abdel-Haq; Basim I Asmar
Journal:  Indian J Pediatr       Date:  2004-01       Impact factor: 5.319

8.  Dominance of variant A in human herpesvirus 6 viraemia after renal transplantation.

Authors:  Eszter Csoma; Beáta Mészáros; Tamás Gáll; László Asztalos; József Kónya; Lajos Gergely
Journal:  Virol J       Date:  2011-08-15       Impact factor: 4.099

Review 9.  Lymphoproliferative Syndromes Associated with Human Herpesvirus-6A and Human Herpesvirus-6B.

Authors:  Eva Eliassen; Gerhard Krueger; Mario Luppi; Dharam Ablashi
Journal:  Mediterr J Hematol Infect Dis       Date:  2018-05-01       Impact factor: 2.576
  9 in total

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