Literature DB >> 7599791

In vitro differentiation and proliferation in a newly established human rhabdomyosarcoma cell line.

A Ogose1, T Motoyama, T Hotta, H Watanabe.   

Abstract

A newly established cell line, designated NRS-1, was derived from an alveolar rhabdomyosarcoma that developed in the left forearm of a 7-year-old girl. The cell line had a t(2; 13) chromosomal translocation. Reverse transcription-polymerase chain reaction demonstrated that 5' PAX3-3' FKHR chimeric transcript was expressed in NRS-1 cells. NRS-1 cells showed myogenic differentiation without any particular stimulus in vitro and exhibited various kinds of muscle markers. All-trans retinoic acid promoted cell differentiation in the myogenic direction. Transforming growth factor-beta (TGF-beta) inhibited myogenic differentiation of those cells and promoted cell proliferation.

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Year:  1995        PMID： 7599791     DOI： 10.1007/BF00191348

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  29 in total

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Journal:  Nat Genet       Date:  1993-11       Impact factor: 38.330

5.  Expression of transforming growth factor-beta isoforms in small round cell tumors of childhood. An immunohistochemical study.

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Authors:  L R Kelland; L Bingle; S Edwards; G G Steel
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9.  Cytogenetic and cellular characteristics of a human embryonal rhabdomyosarcoma cell line, RMS-YM.

Authors:  K Kubo; T Naoe; K R Utsumi; Y Ishiguro; K Ueda; H Shiku; K Yamada
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7.  Characterization of a new human embryonal rhabdomyosarcoma cell line, RMS-GR.

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  7 in total

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