Literature DB >> 7599789

Expression of the glycolipid globotriaosylceramide (Gb3) in testicular carcinoma in situ.

J L Kang1, E Rajpert-De Meyts, J Wiels, N E Skakkebaek.   

Abstract

Changes in the cell membrane glycolipid composition and metabolism are frequently associated with carcinogenesis. The accumulation of globo-series glycolipids is the most notable change of the germ cell glycolipid composition observed in testicular tumours. In this study, the expression of the globo-series core-structure, globotriaosylceramide (Gb3) was investigated in the preinvasive stage of testicular germ cell tumours, carcinoma in situ (CIS). Seventeen tissue specimens with CIS and 12 samples of overt testicular tumours were immunostained with anti-Gb3 monoclonal antibody 38-13. The accumulation of Gb3 was detected in 12 CIS samples (70.6%) and in 8 invasive tumour samples (66.7%), including seminoma, non-seminoma and a combined germ cell tumour. Our findings indicate that the composition of glycolipids shift at the common preinvasive stage of testicular germ cell tumours and confirm that Gb3 is a tumour-associated antigen of testicular germ cell neoplasia.

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Year:  1995        PMID： 7599789     DOI： 10.1007/BF00191346

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  23 in total

1.  Carcinoma in situ in atrophic testis: biopsy based on abnormal ultrasound pattern.

Authors:  A Giwercman; S Lenz; N E Skakkebaek
Journal:  Br J Urol       Date:  1993-07

2.  Placental-like alkaline phosphatase as a marker of carcinoma-in-situ of the testis. Comparison with monoclonal antibodies M2A and 43-9F.

Authors:  A Giwercman; L Cantell; A Marks
Journal:  APMIS       Date:  1991-07       Impact factor: 3.205

3.  Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma.

Authors:  N E Skakkebaek; J G Berthelsen; A Giwercman; J Müller
Journal:  Int J Androl       Date:  1987-02

4.  Changes in glycolipid expression in human testicular tumor.

Authors:  C Ohyama; Y Fukushi; M Satoh; S Saitoh; S Orikasa; E Nudelman; M Straud; S Hakomori
Journal:  Int J Cancer       Date:  1990-06-15       Impact factor: 7.396

5.  Globotriaosyl ceramide glycolipid in seminoma: its clinicopathological importance in differentiation from testicular malignant lymphoma.

Authors:  C Ohyama; S Orikasa; M Satoh; S Saito; H Ohtani; Y Fukushi
Journal:  J Urol       Date:  1992-07       Impact factor: 7.450

6.  Characterization of a human melanoma-associated ganglioside antigen defined by a monoclonal antibody, 4.2.

Authors:  E Nudelman; S Hakomori; R Kannagi; S Levery; M Y Yeh; K E Hellström; I Hellström
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157

7.  Enzymatic and organizational difference in expression of a Burkitt lymphoma-associated antigen (globotriaosylceramide) in Burkitt lymphoma and lymphoblastoid cell lines.

Authors:  J Wiels; E H Holmes; N Cochran; T Tursz; S Hakomori
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

8.  Immunohistochemical localization of murine stage-specific embryonic antigens in human testicular germ cell tumors.

Authors:  I Damjanov; N Fox; B B Knowles; D Solter; P H Lange; E E Fraley
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

9.  New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3.

Authors:  R Kannagi; S B Levery; F Ishigami; S Hakomori; L H Shevinsky; B B Knowles; D Solter
Journal:  J Biol Chem       Date:  1983-07-25       Impact factor: 5.157

10.  Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside isolated from human teratocarcinoma cells.

Authors:  R Kannagi; N A Cochran; F Ishigami; S Hakomori; P W Andrews; B B Knowles; D Solter
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  6 in total

1.  Enzymatic synthesis of Gb3 and iGb3 ceramides.

Authors:  Dietlind Adlercreutz; Joel T Weadge; Bent O Petersen; Jens Ø Duus; Norman J Dovichi; Monica M Palcic
Journal:  Carbohydr Res       Date:  2010-02-13       Impact factor: 2.104

2.  Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.

Authors:  E Rajpert-De Meyts; S N Poll; I Goukasian; C Jeanneau; A S Herlihy; E P Bennett; N E Skakkebaek; H Clausen; A Giwercman; U Mandel
Journal:  Virchows Arch       Date:  2007-08-11       Impact factor: 4.064

Review 3.  Verotoxin-1 treatment or manipulation of its receptor globotriaosylceramide (gb3) for reversal of multidrug resistance to cancer chemotherapy.

Authors:  Parviz Behnam-Motlagh; Andreas Tyler; Kjell Grankvist; Anders Johansson
Journal:  Toxins (Basel)       Date:  2010-10-25       Impact factor: 4.546

4.  Glycolipids of human primary testicular germ cell tumours.

Authors:  R A Olie; B Fenderson; K Daley; J W Oosterhuis; J Murphy; L H Looijenga
Journal:  Br J Cancer       Date:  1996-07       Impact factor: 7.640

5.  Fabry disease and incidence of cancer.

Authors:  Sarah Bird; Efthymios Hadjimichael; Atul Mehta; Uma Ramaswami; Derralynn Hughes
Journal:  Orphanet J Rare Dis       Date:  2017-09-06       Impact factor: 4.123

Review 6.  Role of Globotriaosylceramide in Physiology and Pathology.

Authors:  Ana Beatriz Celi; Jorge Goldstein; María Victoria Rosato-Siri; Alipio Pinto
Journal:  Front Mol Biosci       Date:  2022-02-23
  6 in total

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