A M Hussein1, A Stuart, W P Peters. 1. Bone Marrow Transplant Program, Duke University Medical Center, Durham, N.C., USA.
Abstract
BACKGROUND: We have previously shown that several agents will protect against chemotherapy-induced alopecia in the newborn rat animal model. Such protective agents render the hair follicle keratinocytes resistant to chemotherapy possibly by the expression of P-glycoprotein (Pgp). Cyclosporin A (CSA) is a potent inhibitor of Pgp. METHODS AND RESULTS: Efficacy of CSA was tested in its effects on chemotherapy-induced alopecia in the newborn rat animal model. CSA, when applied topically, protected rats from local alopecia induced by various agents. CONCLUSION: The mechanism of protection by CSA and its relationship to Pgp remain uncertain. The potential clinical applicability of this observation remains to be determined.
BACKGROUND: We have previously shown that several agents will protect against chemotherapy-induced alopecia in the newborn rat animal model. Such protective agents render the hair follicle keratinocytes resistant to chemotherapy possibly by the expression of P-glycoprotein (Pgp). Cyclosporin A (CSA) is a potent inhibitor of Pgp. METHODS AND RESULTS: Efficacy of CSA was tested in its effects on chemotherapy-induced alopecia in the newborn rat animal model. CSA, when applied topically, protected rats from local alopecia induced by various agents. CONCLUSION: The mechanism of protection by CSA and its relationship to Pgp remain uncertain. The potential clinical applicability of this observation remains to be determined.
Authors: Christopher John Dunnill; Wafaa Al-Tameemi; Andrew Collett; Iain Stuart Haslam; Nikolaos Theodoros Georgopoulos Journal: Oncologist Date: 2017-09-26
Authors: Paul J Hesketh; Diane Batchelor; Mitch Golant; Gary H Lyman; Nelson Rhodes; Denise Yardley Journal: Support Care Cancer Date: 2004-06-19 Impact factor: 3.603