Literature DB >> 7599321

BCR/ABL signal transduction.

T Tauchi1, H E Broxmeyer.   

Abstract

A strong association between the Philadelphia chromosome (Ph1) and chronic myelogenous leukemia (CML) suggests that the Ph1 translocation plays a significant role in pathogenesis of CML. For this reason, Ph1-positive leukemias have been well studied from the molecular, clinical and cell biological perspective. In this review article, intracellular signalling events involving BCR/ABL fusion gene products are discussed in the context of the role of the Ph1 chromosome in human leukemia.

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Year:  1995        PMID： 7599321     DOI： 10.1016/0925-5710(95)00361-u

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  4 in total

1.  Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.

Authors:  E M Weissinger; G Eissner; C Grammer; S Fackler; B Haefner; L S Yoon; K S Lu; A Bazarov; J M Sedivy; H Mischak; W Kolch
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

Review 2.  Imatinib mesylate in combination with other chemotherapeutic agents for chronic myelogenous leukemia.

Authors:  Tetsuzo Tauchi; Kazuma Ohyashiki
Journal:  Int J Hematol       Date:  2004-06       Impact factor: 2.490

3.  Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate.

Authors:  Takeyoshi Itsukuma; Hideki Ishikawa; Mahito Misawa; Shunro Kai; Yoshihiro Fujimori; Kazuhiko Nakagawa; Seiichi Hirota; Ayako Sugihara; Nobuyuki Terada; Hiroshi Hara
Journal:  J Gastroenterol       Date:  2007-05-25       Impact factor: 7.527

4.  Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells.

Authors:  Chun Chen; Yingting Zhuang; Xianling Chen; Xiaole Chen; Ding Li; Yingjuan Fan; Jianhua Xu; Yuanzhong Chen; Lixian Wu
Journal:  Oncotarget       Date:  2017-02-07
  4 in total

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