OBJECTIVE: To find out the safe time limit for Pringle's manoeuvre (compression of the hepatic artery and portal vein in the gastrohepatic omentum to halt bleeding) under normal environmental conditions for limited resection of cirrhotic livers. DESIGN: Prospective open study. SETTING: University hospital, Japan. SUBJECTS: Pringle's manoeuvre was used in 73 consecutive patients with hepatocellular carcinoma and cirrhosis (Child's classification: A = 44, B = 24, and C = 5), and in 20 patients it was not used (Child's classification: A = 11, B = 5, and C = 4). INTERVENTIONS: Limited hepatic resections were done with the duration of Pringle's manoeuvre ranging from 5 to 41 minutes. 15 patients simultaneously underwent 17 other abdominal operations. MAIN OUTCOME MEASURES: Child's classification, blood loss during operation, and duration of hepatic ischaemia. RESULTS: The morbidity and mortality with Pringle's manoeuvre were 1 (2%) and 0 in Child's A cirrhosis, 7 (29%) and 2 (8%) in Child's B cirrhosis, and 2 (40%) and 1 (20%) in Child's C cirrhosis. The higher rates in class B and C patients were ascribed to the amount of blood loss rather than to Pringle's manoeuvre. CONCLUSION: Pringle's manoeuvre can be used safely for up to 30 minutes during limited resection of the cirrhotic liver.
OBJECTIVE: To find out the safe time limit for Pringle's manoeuvre (compression of the hepatic artery and portal vein in the gastrohepatic omentum to halt bleeding) under normal environmental conditions for limited resection of cirrhotic livers. DESIGN: Prospective open study. SETTING: University hospital, Japan. SUBJECTS: Pringle's manoeuvre was used in 73 consecutive patients with hepatocellular carcinoma and cirrhosis (Child's classification: A = 44, B = 24, and C = 5), and in 20 patients it was not used (Child's classification: A = 11, B = 5, and C = 4). INTERVENTIONS: Limited hepatic resections were done with the duration of Pringle's manoeuvre ranging from 5 to 41 minutes. 15 patients simultaneously underwent 17 other abdominal operations. MAIN OUTCOME MEASURES: Child's classification, blood loss during operation, and duration of hepatic ischaemia. RESULTS: The morbidity and mortality with Pringle's manoeuvre were 1 (2%) and 0 in Child's A cirrhosis, 7 (29%) and 2 (8%) in Child's B cirrhosis, and 2 (40%) and 1 (20%) in Child's C cirrhosis. The higher rates in class B and C patients were ascribed to the amount of blood loss rather than to Pringle's manoeuvre. CONCLUSION: Pringle's manoeuvre can be used safely for up to 30 minutes during limited resection of the cirrhotic liver.
Authors: F Oldhafer; K I Ringe; K Timrott; M Kleine; O Beetz; W Ramackers; S Cammann; J Klempnauer; H Bektas; Florian W R Vondran Journal: Langenbecks Arch Surg Date: 2019-06-29 Impact factor: 3.445
Authors: Harmeet Malhi; Giridhar R Gorla; Adil N Irani; Pallavi Annamaneni; Sanjeev Gupta Journal: Proc Natl Acad Sci U S A Date: 2002-09-20 Impact factor: 11.205
Authors: F Oldhafer; K I Ringe; K Timrott; M Kleine; O Beetz; W Ramackers; S Cammann; J Klempnauer; F W R Vondran; H Bektas Journal: Langenbecks Arch Surg Date: 2018-02-22 Impact factor: 3.445