Literature DB >> 7599191

Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.

S Kobayashi1, J Ohnishi, Y Nibu, S Nishimatsu, S Umemura, M Ishii, K Murakami, H Miyazaki.   

Abstract

We have cloned the rat angiotensin II receptor type 2 (AT2) gene, whose physiological function remains unclear. Sequence analysis indicated that exons 1 and 2 exist in the 5'-untranslated region and the initiation codon ATG is located in exon 3. The 1.6-kb genomic fragment at positions -1567 to +26 relative to the putative transcription start site was found to contain a functional promoter region using transient chloramphenicol acetyltransferase assay. This is the first report demonstrating the nucleotide sequence of the promoter region of this gene.

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Year:  1995        PMID： 7599191     DOI： 10.1016/0167-4781(95)00076-s

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

Authors:  G Wolf; F N Ziyadeh; F Thaiss; J Tomaszewski; R J Caron; U Wenzel; G Zahner; U Helmchen; R A Stahl
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

2.  Efficient transcription of the human angiotensin II type 2 receptor gene requires intronic sequence elements.

Authors:  C Warnecke; T Willich; J Holzmeister; S P Bottari; E Fleck; V Regitz-Zagrosek
Journal:  Biochem J       Date:  1999-05-15       Impact factor: 3.857

3.  Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation.

Authors:  Syeda H Afroze; Md Kamruzzaman Munshi; Allyson K Martínez; Mohammad Uddin; Maté Gergely; Claudia Szynkarski; Micheleine Guerrier; Damir Nizamutdinov; David Dostal; Shannon Glaser
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2015-02-12       Impact factor: 4.052

Review 4.  The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target.

Authors:  U Muscha Steckelings; Robert E Widdop; Edward D Sturrock; Lizelle Lubbe; Tahir Hussain; Elena Kaschina; Thomas Unger; Anders Hallberg; Robert M Carey; Colin Sumners
Journal:  Pharmacol Rev       Date:  2022-10       Impact factor: 18.923

5.  Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats.

Authors:  Miroslava Macova; Ines Armando; Jin Zhou; Gustavo Baiardi; Dmitri Tyurmin; Ignacio M Larrayoz-Roldan; Juan M Saavedra
Journal:  Neuroendocrinology       Date:  2008-08-04       Impact factor: 4.914

6.  Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats.

Authors:  Jay S Mishra; Kathirvel Gopalakrishnan; Sathish Kumar
Journal:  Biol Reprod       Date:  2018-11-01       Impact factor: 4.285
  6 in total

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