| Literature DB >> 7599184 |
S Wiese1, D B Murphy, A Schlung, P Burfeind, D Schmundt, V Schnülle, M G Mattei, U Thies.
Abstract
Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.Entities:
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Year: 1995 PMID： 7599184 DOI： 10.1016/0167-4781(95)00059-p
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002