Synthesis and antimicrobial activity of some new carbazoles, indazoles, quinolines, quinazolines and naphthalenes from 3-methyl-5-phenyl-6-benzylidene-2-cyclohexene-1-one.

Reaction of the title compound (1) with phenylhydrazine using the Fisher indole synthesis, resulted in the formation of the carbazole derivative (2). Condensation of (1) benzaldehyde afforded the 6-benzylidene derivative (3). Treatment of compound (3) with some hydrazines and hydrazides resulted in the formation of the indazoles (4). Michael addition of some active methylene components with (3) gave quinolines (5) and naphthalenes (7). The reaction of (3) with urea and thiourea gave the uraciles (6). The newly synthesized compounds were screened for antibacterial activity.