OBJECTIVE: Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDS patient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emergency room in acute renal failure. METHODS/ RESULTS: Obstructive uropathy due to radiolucent calculi was suspected and retrograde ureteral catheterization was necessary. The calculi recovered were identified as N-acetyl sulfadiazine by infrared spectrophotometry. CONCLUSION: Rapid improvement can be achieved in these patients when the drug is discontinued or decrease and systemic fluid and urine alkalinization are started.
OBJECTIVE: Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDSpatient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emergency room in acute renal failure. METHODS/ RESULTS: Obstructive uropathy due to radiolucent calculi was suspected and retrograde ureteral catheterization was necessary. The calculi recovered were identified as N-acetyl sulfadiazine by infrared spectrophotometry. CONCLUSION: Rapid improvement can be achieved in these patients when the drug is discontinued or decrease and systemic fluid and urine alkalinization are started.
Authors: Charlotte Catalano-Pons; Sophie Bargy; Deborah Schlecht; Marie-Dominique Tabone; George Deschênes; Albert Bensman; Tim Ulinski Journal: Pediatr Nephrol Date: 2004-06-17 Impact factor: 3.714