| Literature DB >> 7598462 |
Abstract
Platelet aggregation is one of the best understood examples of adhesive cell-cell interactions. The platelet glycoprotein IIb/IIIa membrane receptor plays a pivotal role in platelet aggregation through its binding of fibrinogen. It is intimately involved in the pathogenesis of platelet-rich arterial thromboses. The IIb/IIIa receptor is an important target for recently described novel antiplatelet therapeutics. The development and clinical evaluation of this class of antiplatelet therapeutics are reviewed in this article.Entities:
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Year: 1995 PMID： 7598462 DOI： 10.1146/annurev.med.46.1.257
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739