Literature DB >> 7598450

Molecular approaches to amyotrophic lateral sclerosis.

R G Smith1, S H Appel.   

Abstract

New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.

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Year:  1995        PMID： 7598450     DOI： 10.1146/annurev.med.46.1.133

Source DB:  PubMed          Journal:  Annu Rev Med        ISSN： 0066-4219            Impact factor:   13.739


  8 in total

1.  A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q.

Authors:  Collette K Hand; Jawad Khoris; François Salachas; François Gros-Louis; Ana Amélia Simões Lopes; Veronique Mayeux-Portas; Carl G Brewer; Robert H Brown; Vincent Meininger; William Camu; Guy A Rouleau
Journal:  Am J Hum Genet       Date:  2001-11-09       Impact factor: 11.025

2.  Reduced glutathione in amyotrophic lateral sclerosis: an open, crossover, randomized trial.

Authors:  A Chiò; A Cucatto; A A Terreni; D Schiffer
Journal:  Ital J Neurol Sci       Date:  1998-12

3.  Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2.

Authors:  R J Singh; H Karoui; M R Gunther; J S Beckman; R P Mason; B Kalyanaraman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

4.  Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase.

Authors:  M Peled-Kamar; J Lotem; I Wirguin; L Weiner; A Hermalin; Y Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

5.  Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

Authors:  O Bar-Peled; E Korkotian; M Segal; Y Groner
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-06       Impact factor: 11.205

6.  Transgenic mice for interleukin 3 develop motor neuron degeneration associated with autoimmune reaction against spinal cord motor neurons.

Authors:  C Chavany; C Vicario-Abejón; G Miller; M Jendoubi
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-15       Impact factor: 11.205

Review 7.  The perplexing role of copper-zinc superoxide dismutase in amyotrophic lateral sclerosis (Lou Gehrig's disease).

Authors:  Soshanna Zittin Potter; Joan Selverstone Valentine
Journal:  J Biol Inorg Chem       Date:  2003-03-19       Impact factor: 3.358

8.  Axotomized neonatal motoneurons overexpressing the bcl2 proto-oncogene retain functional electrophysiological properties.

Authors:  S Alberi; M Raggenbass; F de Bilbao; M Dubois-Dauphin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205
  8 in total

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