Literature DB >> 7598304

Interferon-gamma in the management of infectious diseases.

J I Gallin1, J M Farber, S M Holland, T B Nutman.   

Abstract

Interferon-gamma has pleiotropic adjuvant effects on host defenses. These effects have made interferon-gamma particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-gamma will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-gamma is emerging as an important cytokine for use in the treatment of infectious diseases.

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Year:  1995        PMID： 7598304     DOI： 10.7326/0003-4819-123-3-199508010-00009

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN： 0003-4819            Impact factor:   25.391


  23 in total

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