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Literature DB >> 7597049

Identification of a nonneuronal isoform of synaptotagmin.

Abstract

Synaptotagmins, which have been found exclusively in neuroendocrine or exocrine tissues, have been implicated in the regulation of secretory vesicle fusion with the plasma membrane. The present paper describes a synaptotagmin isoform (synaptotagmin-5) which exhibits 49% amino acid identity to synaptotagmin-1 and -2. Synaptotagmin-5 mRNA is expressed in rat kidney, adipose tissue, lung, and heart, as well as at higher levels in brain and PC12 cells. Antiserum specific for the synaptotagmin-5 isoform recognizes a protein of about 50 kDa which is about 6-fold more abundant in brain synaptic vesicles than in whole brain membranes.

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Year: 1995 PMID： 7597049 PMCID： PMC41608 DOI： 10.1073/pnas.92.13.5895

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

42 in total

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Authors: M L Nonet; K Grundahl; B J Meyer; J B Rand
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6. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.

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Authors: A DiAntonio; T L Schwarz
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19 in total

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Authors: Ping Wang; Michael C Chicka; Akhil Bhalla; David A Richards; Edwin R Chapman
Journal: Mol Cell Biol Date: 2005-10 Impact factor: 4.272

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6. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.

Authors: Guo Zhang; Hua Bai; Hai Zhang; Camin Dean; Qiang Wu; Juxue Li; Sara Guariglia; Qingyuan Meng; Dongsheng Cai
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7. Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells.

Authors: M Ohara-Imaizumi; M Fukuda; M Niinobe; H Misonou; K Ikeda; T Murakami; M Kawasaki; K Mikoshiba; K Kumakura
Journal: Proc Natl Acad Sci U S A Date: 1997-01-07 Impact factor: 11.205

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Journal: J Neurosci Date: 1997-02-15 Impact factor: 6.167

9. Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.

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Journal: Biochem J Date: 1996-12-01 Impact factor: 3.857

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Authors: Mitsunori Fukuda; Yukie Ogata; Chika Saegusa; Eiko Kanno; Katsuhiko Mikoshiba
Journal: Biochem J Date: 2002-07-01 Impact factor: 3.857