Literature DB >> 7594449

Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.

V P Poltoratsky1, X Shi, J D York, M R Lieber, T H Carter.   

Abstract

DNA-activated protein kinase (DNA-PK) is a serine/threonine protein kinase that interacts with a DNA end-binding heterodimeric protein, Ku, and is activated by double-stranded DNA. Genomic clones that contain the DNA-PK gene complement the murine scid defect, indicating that DNA-PK affects double-strand break repair and V(D)J recombination. Here we describe the cDNA sequence of the region that corresponds to about 100 kDa of C-terminal sequence of this large (> p350 kDa) protein. This region contains a kinase domain that has strong homology to phosphatidylinositol kinases.

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Year:  1995        PMID： 7594449

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  12 in total

1.  The influence of DNA double-strand break structure on end-joining in human cells.

Authors:  J Smith; C Baldeyron; I De Oliveira; M Sala-Trepat; D Papadopoulo
Journal:  Nucleic Acids Res       Date:  2001-12-01       Impact factor: 16.971

2.  Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20.

Authors:  A Priestley; H J Beamish; D Gell; A G Amatucci; M C Muhlmann-Diaz; B K Singleton; G C Smith; T Blunt; L C Schalkwyk; J S Bedford; S P Jackson; P A Jeggo; G E Taccioli
Journal:  Nucleic Acids Res       Date:  1998-04-15       Impact factor: 16.971

3.  Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines.

Authors:  Sadayuki Ban; Yuichi Michikawa; Ken-ichi Ishikawa; Masashi Sagara; Koji Watanabe; Yutaka Shimada; Johji Inazawa; Takashi Imai
Journal:  Int J Exp Pathol       Date:  2005-08       Impact factor: 1.925

4.  Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.

Authors:  L J Kienker; E K Shin; K Meek
Journal:  Nucleic Acids Res       Date:  2000-07-15       Impact factor: 16.971

5.  Activation of Tel1ATM kinase requires Rad50 ATPase and long nucleosome-free DNA but no DNA ends.

Authors:  Sarem Hailemariam; Sandeep Kumar; Peter M Burgers
Journal:  J Biol Chem       Date:  2019-05-09       Impact factor: 5.157

Review 6.  Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.

Authors:  W S Dynan; S Yoo
Journal:  Nucleic Acids Res       Date:  1998-04-01       Impact factor: 16.971

7.  The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

Authors:  F A Goytisolo; E Samper; S Edmonson; G E Taccioli; M A Blasco
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

8.  Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice.

Authors:  R Araki; A Fujimori; K Hamatani; K Mita; T Saito; M Mori; R Fukumura; M Morimyo; M Muto; M Itoh; K Tatsumi; M Abe
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

9.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 10.  The role of DNA-PK in aging and energy metabolism.

Authors:  Jay H Chung
Journal:  FEBS J       Date:  2018-03-12       Impact factor: 5.542
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