Literature DB >> 7592906

Raf-1 is activated during mitosis.

A D Laird1, S J Taylor, M Oberst, D Shalloway.   

Abstract

The Raf-1 serine/threonine kinase transmits proliferative and developmental signals to downstream effectors in the mitogen-activated protein kinase cascade. Studies to date have concentrated on its role in growth factor-mediated activation of the cell cycle. We show here that Raf-1 kinase activity is also highly stimulated during mitosis, with an attendant distinctive electrophoretic mobility shift due to hyperphosphorylation. These results suggest that Raf-1 may play a role in traversal of at least two distinct phases of the cell cycle.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7592906     DOI： 10.1074/jbc.270.45.26742

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  8 in total

1.  PTP-S2, a nuclear tyrosine phosphatase, is phosphorylated and excluded from condensed chromosomes during mitosis.

Authors:  S Nambirajan; V Radha; S Kamatkar; G Swarup
Journal:  J Biosci       Date:  2000-03       Impact factor: 1.826

2.  Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.

Authors:  S Dangi; F M Chen; P Shapiro
Journal:  Cell Prolif       Date:  2006-08       Impact factor: 6.831

3.  Transcriptional regulation of the Drosophila-raf proto-oncogene by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system.

Authors:  J R Ryu; T Y Choi; E J Kwon; W H Lee; Y Nishida; Y Hayashi; A Matsukage; M Yamaguchi; M A Yoo
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

4.  Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.

Authors:  J C Bitangcol; A S Chau; E Stadnick; M J Lohka; B Dicken; E K Shibuya
Journal:  Mol Biol Cell       Date:  1998-02       Impact factor: 4.138

5.  Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.

Authors:  M Di Fruscio; T Chen; S Richard
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

6.  RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition.

Authors:  Gudrun Reiterer; Lihua Chen; Ryan Tassef; Jeffery D Varner; Chang-Yan Chen; Andrew Yen
Journal:  Cell Cycle       Date:  2010-08-10       Impact factor: 5.173

7.  Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis.

Authors:  Elisabeth C Roberts; Paul S Shapiro; Theresa Stines Nahreini; Gilles Pages; Jacques Pouyssegur; Natalie G Ahn
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

8.  Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen.

Authors:  P S Shapiro; E Vaisberg; A J Hunt; N S Tolwinski; A M Whalen; J R McIntosh; N G Ahn
Journal:  J Cell Biol       Date:  1998-09-21       Impact factor: 10.539
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.