Literature DB >> 7592021

Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.

S Stella1, N Montanini, F Le Monnier, P Ferrari, L Colombo, F Marinelli, P Landini, I Ciciliato, B P Goldstein, E Selva.   

Abstract

GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7592021     DOI： 10.7164/antibiotics.48.780

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  8 in total

1.  Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy.

Authors:  Kelly E Bird; Christian Xander; Sebastian Murcia; Alan A Schmalstig; Xianxi Wang; Michael J Emanuele; Miriam Braunstein; Albert A Bowers
Journal:  ACS Chem Biol       Date:  2020-07-14       Impact factor: 5.100

2.  Identification of the thiazolyl peptide GE37468 gene cluster from Streptomyces ATCC 55365 and heterologous expression in Streptomyces lividans.

Authors:  Travis S Young; Christopher T Walsh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

3.  Antimicrobial evaluation of nocathiacins, a thiazole peptide class of antibiotics.

Authors:  Michael J Pucci; Joanne J Bronson; John F Barrett; Kenneth L DenBleyker; Linda F Discotto; Joan C Fung-Tomc; Yasutsugu Ueda
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

4.  Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.

Authors:  Travis S Young; Pieter C Dorrestein; Christopher T Walsh
Journal:  Chem Biol       Date:  2012-12-21

Review 5.  YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Authors:  Brandon J Burkhart; Christopher J Schwalen; Greg Mann; James H Naismith; Douglas A Mitchell
Journal:  Chem Rev       Date:  2017-03-03       Impact factor: 60.622

Review 6.  α,β-Dehydroamino acids in naturally occurring peptides.

Authors:  Dawid Siodłak
Journal:  Amino Acids       Date:  2014-10-17       Impact factor: 3.520

Review 7.  Trends in therapeutic drug conjugates for bacterial diseases: a patent review.

Authors:  Pedro M S D Cal; Maria J Matos; Gonçalo J L Bernardes
Journal:  Expert Opin Ther Pat       Date:  2016-11-23       Impact factor: 6.674

8.  Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris.

Authors:  Jesús Martín; Thiciana da S Sousa; Gloria Crespo; Sara Palomo; Ignacio González; José R Tormo; Mercedes de la Cruz; Matthew Anderson; Russell T Hill; Francisca Vicente; Olga Genilloud; Fernando Reyes
Journal:  Mar Drugs       Date:  2013-02-04       Impact factor: 5.118
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.