Literature DB >> 7591592

Human chorionic gonadotropin in serum and neoplastic tissue from patients with bladder carcinoma.

S Baltaci1, S Küpeli, S D Sak, E Erden, K Sarica.   

Abstract

Serum levels and tissue expression of beta subunit of human chorionic gonadotropin were determined in 25 patients with bladder carcinoma. Elevated gonadotropin levels in serum were observed in 5 (20%) patients and immunoreactive cells were found in 5 (20%) tumours. The correlation was poor between serum level and immunohistochemical gonadotropin status. Only one patient showed both elevated serum level and immunohistochemical gonadotropin expression. Our observations suggest that elevated serum levels of gonadotropin may be an indicator of poor prognosis. However, immunohistochemical expression of gonadotropin did not seem to have a similar impact on prognosis in this series.

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Year:  1995        PMID： 7591592     DOI： 10.1007/BF02564764

Source DB:  PubMed          Journal:  Int Urol Nephrol        ISSN： 0301-1623            Impact factor:   2.370


  14 in total

Review 1.  Human chorionic gonadotropin expression by bladder cancers: biology and clinical potential.

Authors:  R K Iles; T Chard
Journal:  J Urol       Date:  1991-03       Impact factor: 7.450

2.  Carcinoembryonic antigen and beta-human chorionic gonadotropin as serum markers for advanced urothelial malignancies.

Authors:  F Dexeus; C Logothetis; E Hossan; M L Samuels
Journal:  J Urol       Date:  1986-08       Impact factor: 7.450

3.  Trophoblastic metaplasia in urothelial carcinoma of the bladder.

Authors:  A F Burry; S R Munn; E P Arnold; C U McRae
Journal:  Br J Urol       Date:  1986-04

4.  Bladder carcinoma associated with ectopic production of gonadotropin.

Authors:  J Kawamura; S Machida; O Yoshida; F Oseko; H Imura; M Hattori
Journal:  Cancer       Date:  1978-12       Impact factor: 6.860

5.  Human chorionic gonadotropin detected in urinary concentrates from patients with malignant tumors of the testis, prostate, bladder, ureter and kidney.

Authors:  K Fukutani; J M Libby; W B Panko; P T Scardino
Journal:  J Urol       Date:  1983-01       Impact factor: 7.450

6.  Immunohistochemical demonstration of human chorionic gonadotropin in tumors of the urinary bladder.

Authors:  H T Yamase; R S Wurzel; P T Nieh; B Gondos
Journal:  Ann Clin Lab Sci       Date:  1985 Sep-Oct       Impact factor: 1.256

7.  Ectopic beta-human chorionic gonadotropin production by bladder urothelial neoplasia.

Authors:  V M Shah; J Newman; J Crocker; C R Chapple; M J Collard; J M O'Brien; J Considine
Journal:  Arch Pathol Lab Med       Date:  1986-02       Impact factor: 5.534

8.  Immunohistochemical localization and chromatographic characterization of human chorionic gonadotropin in a bladder carcinoma.

Authors:  C J Rodenburg; A C Nieuwenhuyzen Kruseman; H A de Maaker; G J Fleuren; A T van Oosterom
Journal:  Arch Pathol Lab Med       Date:  1985-11       Impact factor: 5.534

9.  Evaluation of a new bladder tumor marker.

Authors:  H B Grossman; M Liebert; N Sakakibara; G A Wedemeyer; J A Stein; R W Washington
Journal:  Urol Clin North Am       Date:  1991-08       Impact factor: 2.241

10.  Placental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein.

Authors:  E Campo; F Algaba; A Palacin; R Germa; F J Sole-Balcells; A Cardesa
Journal:  Cancer       Date:  1989-06-15       Impact factor: 6.860
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