Literature DB >> 7591282

Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.

M Bailly1, C Bain, M C Favrot, M Ozturk.   

Abstract

Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations.

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Year:  1995        PMID： 7591282     DOI： 10.1002/ijc.2910630510

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  5 in total

1.  Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma.

Authors:  Alison C Young; Rachel A Craven; Dena Cohen; Claire Taylor; Christopher Booth; Patricia Harnden; David A Cairns; Dewi Astuti; Walter Gregory; Eamonn R Maher; Margaret A Knowles; Adrian Joyce; Peter J Selby; Rosamonde E Banks
Journal:  Clin Cancer Res       Date:  2009-12-15       Impact factor: 12.531

2.  VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.

Authors:  Michelle J Nyhan; Shereen M El Mashad; Tracey R O'Donovan; Sarfraz Ahmad; Chris Collins; Paul Sweeney; Eamonn Rogers; Gerald C O'Sullivan; Sharon L McKenna
Journal:  Cell Oncol (Dordr)       Date:  2011-05-06       Impact factor: 6.730

3.  Software and database for the analysis of mutations in the VHL gene.

Authors:  C Béroud; D Joly; C Gallou; F Staroz; M T Orfanelli; C Junien
Journal:  Nucleic Acids Res       Date:  1998-01-01       Impact factor: 16.971

4.  A novel missense mutation (N78D) in a family with von Hippel-Lindau disease with central nervous system haemangioblastomas, pancreatic and renal cysts.

Authors:  S Cingoz; R B van der Luijt; E Kurt; M Apaydin; I Akkol; Mihriban Heval Ozgen
Journal:  Fam Cancer       Date:  2013-03       Impact factor: 2.375

5.  Prevalence of von Hippel-Lindau gene mutations in sporadic renal cell carcinoma: results from The Netherlands cohort study.

Authors:  Kjeld P van Houwelingen; Boukje A C van Dijk; Christina A Hulsbergen-van de Kaa; Leo J Schouten; Hanneke J M Gorissen; Jack A Schalken; Piet A van den Brandt; Egbert Oosterwijk
Journal:  BMC Cancer       Date:  2005-06-02       Impact factor: 4.430
  5 in total

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