Literature DB >> 7591100

Regulation of virulence by environmental signals in group A streptococci: influence of osmolarity, temperature, gas exchange, and iron limitation on emm transcription.

K S McIver1, A S Heath, J R Scott.   

Abstract

Transcription of the gene encoding the antiphagocytic M protein (emm) of the group A streptococci has been shown to be regulated by CO2 (M. G. Caparon, R. T. Geist, J. Perez-Casal, and J. R. Scott, J. Bacteriol. 174:5693-5701, 1992). We tested the influence of additional environmental growth conditions on emm expression. Increased osmolarity, low temperature, growth with free exchange of gasses, or the restricted availability of iron resulted in decreased transcription from the emm promoter.

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Year:  1995        PMID： 7591100      PMCID： PMC173649          DOI： 10.1128/iai.63.11.4540-4542.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  30 in total

Review 1.  Structure, function, and genetics of streptococcal M protein.

Authors:  V A Fischetti; K F Jones; S K Hollingshead; J R Scott
Journal:  Rev Infect Dis       Date:  1988 Jul-Aug

2.  Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci.

Authors:  M G Caparon; J R Scott
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

3.  Streptococcus pyogenes type 12 M protein gene regulation by upstream sequences.

Authors:  J C Robbins; J G Spanier; S J Jones; W J Simpson; P P Cleary
Journal:  J Bacteriol       Date:  1987-12       Impact factor: 3.490

4.  A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli.

Authors:  C F Higgins; C J Dorman; D A Stirling; L Waddell; I R Booth; G May; E Bremer
Journal:  Cell       Date:  1988-02-26       Impact factor: 41.582

5.  Positive transcriptional control of mry regulates virulence in the group A streptococcus.

Authors:  N Okada; R T Geist; M G Caparon
Journal:  Mol Microbiol       Date:  1993-03       Impact factor: 3.501

6.  Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis.

Authors:  I Uchida; J M Hornung; C B Thorne; K R Klimpel; S H Leppla
Journal:  J Bacteriol       Date:  1993-09       Impact factor: 3.490

7.  Surface protein-CAT reporter fusions demonstrate differential gene expression in the vir regulon of Streptococcus pyogenes.

Authors:  A Podbielski; J A Peterson; P Cleary
Journal:  Mol Microbiol       Date:  1992-08       Impact factor: 3.501

8.  Introduction of the emm6 gene into an emm-deleted strain of Streptococcus pyogenes restores its ability to resist phagocytosis.

Authors:  J Perez-Casal; M G Caparon; J R Scott
Journal:  Res Microbiol       Date:  1992 Jul-Aug       Impact factor: 3.992

9.  'Toxic strep syndrome'. A manifestation of group A streptococcal infection.

Authors:  T Bartter; A Dascal; K Carroll; F J Curley
Journal:  Arch Intern Med       Date:  1988-06

10.  Cloning and CO2-dependent expression of the genetic region for encapsulation from Bacillus anthracis.

Authors:  S Makino; C Sasakawa; I Uchida; N Terakado; M Yoshikawa
Journal:  Mol Microbiol       Date:  1988-05       Impact factor: 3.501
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  44 in total

1.  Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes.

Authors:  M Unnikrishnan; J Cohen; S Sriskandan
Journal:  Infect Immun       Date:  1999-10       Impact factor: 3.441

2.  Does enterohemorrhagic Escherichia coli O157:H7 enter the viable but nonculturable state in salted salmon roe?

Authors:  S I Makino; T Kii; H Asakura; T Shirahata; T Ikeda; K Takeshi; K Itoh
Journal:  Appl Environ Microbiol       Date:  2000-12       Impact factor: 4.792

3.  Expression of the secondary sigma factor sigmaX in Streptococcus pyogenes is restricted at two levels.

Authors:  Jason A Opdyke; June R Scott; Charles P Moran
Journal:  J Bacteriol       Date:  2003-08       Impact factor: 3.490

4.  Role of Streptococcus pyogenes two-component response regulators in the temporal control of Mga and the Mga-regulated virulence gene emm.

Authors:  Deborah A Ribardo; Thomas J Lambert; Kevin S McIver
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

5.  Identification of isp, a locus encoding an immunogenic secreted protein conserved among group A streptococci.

Authors:  K S McIver; S Subbarao; E M Kellner; A S Heath; J R Scott
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

6.  Absence of SpeB production in virulent large capsular forms of group A streptococcal strain 64.

Authors:  R Raeder; E Harokopakis; S Hollingshead; M D Boyle
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

7.  Characterization of MtsR, a new metal regulator in group A streptococcus, involved in iron acquisition and virulence.

Authors:  Christopher S Bates; Chadia Toukoki; Melody N Neely; Zehava Eichenbaum
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

8.  Identification of residues responsible for the defective virulence gene regulator Mga produced by a natural mutant of Streptococcus pyogenes.

Authors:  Cheryl M Vahling; Kevin S McIver
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490

9.  Role of the C-terminal lysine residues of streptococcal surface enolase in Glu- and Lys-plasminogen-binding activities of group A streptococci.

Authors:  Anne Derbise; Youngmia P Song; Sonia Parikh; Vincent A Fischetti; Vijay Pancholi
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

Review 10.  The structure and function of serum opacity factor: a unique streptococcal virulence determinant that targets high-density lipoproteins.

Authors:  Harry S Courtney; Henry J Pownall
Journal:  J Biomed Biotechnol       Date:  2010-07-08
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