Literature DB >> 7590717

Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.

A M Worm1, A Osterlind.   

Abstract

OBJECTIVE: To determine the kinetics of azithromycin in cervical mucus and plasma. SUBJECTS AND METHODS: Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.
RESULTS: In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.
CONCLUSION: The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.

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Year:  1995        PMID： 7590717      PMCID： PMC1195522          DOI： 10.1136/sti.71.4.244

Source DB:  PubMed          Journal:  Genitourin Med        ISSN： 0266-4348


  14 in total

1.  Selection of dose regimens of azithromycin .

Authors:  G Foulds; R B Johnson
Journal:  J Antimicrob Chemother       Date:  1993-06       Impact factor: 5.790

2.  In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducreyi, and Chlamydia trachomatis.

Authors:  L Slaney; H Chubb; A Ronald; R Brunham
Journal:  J Antimicrob Chemother       Date:  1990-01       Impact factor: 5.790

3.  The pharmacokinetics of azithromycin in human serum and tissues.

Authors:  G Foulds; R M Shepard; R B Johnson
Journal:  J Antimicrob Chemother       Date:  1990-01       Impact factor: 5.790

4.  Comparison of azithromycin and doxycycline in the treatment of non-gonococcal urethritis in men.

Authors:  P J Lister; T Balechandran; G L Ridgway; A J Robinson
Journal:  J Antimicrob Chemother       Date:  1993-06       Impact factor: 5.790

5.  Single-dose oral azithromycin versus seven-day doxycycline in the treatment of non-gonococcal urethritis in males.

Authors:  J Lauharanta; K Saarinen; M T Mustonen; H P Happonen
Journal:  J Antimicrob Chemother       Date:  1993-06       Impact factor: 5.790

6.  Preferential concentration of azithromycin in an infected mouse thigh model.

Authors:  J A Retsema; J M Bergeron; D Girard; W B Milisen; A E Girard
Journal:  J Antimicrob Chemother       Date:  1993-06       Impact factor: 5.790

7.  A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group.

Authors:  D H Martin; T F Mroczkowski; Z A Dalu; J McCarty; R B Jones; S J Hopkins; R B Johnson
Journal:  N Engl J Med       Date:  1992-09-24       Impact factor: 91.245

8.  Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men.

Authors:  O Steingrímsson; J H Olafsson; H Thórarinsson; R W Ryan; R B Johnson; R C Tilton
Journal:  Sex Transm Dis       Date:  1994 Jan-Feb       Impact factor: 2.830

9.  Cultivation of Chlamydia trachomatis in cycloheximide-treated mccoy cells.

Authors:  K T Ripa; P A Mårdh
Journal:  J Clin Microbiol       Date:  1977-10       Impact factor: 5.948

Review 10.  Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications.

Authors:  R H Drew; H A Gallis
Journal:  Pharmacotherapy       Date:  1992       Impact factor: 4.705
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  6 in total

Review 1.  Chlamydiae as pathogens: new species and new issues.

Authors:  R W Peeling; R C Brunham
Journal:  Emerg Infect Dis       Date:  1996 Oct-Dec       Impact factor: 6.883

2.  Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection.

Authors:  William M Geisler; Apurva Uniyal; Jeannette Y Lee; Shelly Y Lensing; Shacondra Johnson; Raymond C W Perry; Carmel M Kadrnka; Peter R Kerndt
Journal:  N Engl J Med       Date:  2015-12-24       Impact factor: 91.245

Review 3.  Azithromycin. A pharmacoeconomic review of its use as a single-dose regimen in the treatment of uncomplicated urogenital Chlamydia trachomatis infections in women.

Authors:  A P Lea; H M Lamb
Journal:  Pharmacoeconomics       Date:  1997-11       Impact factor: 4.981

4.  A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol.

Authors:  Jane S Hocking; Lenka A Vodstrcil; Wilhelmina M Huston; Peter Timms; Marcus Y Chen; Karen Worthington; Ruthy McIver; Sepehr N Tabrizi
Journal:  BMC Infect Dis       Date:  2013-08-17       Impact factor: 3.090

5.  Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS).

Authors:  Lenka A Vodstrcil; Thusitha W T Rupasinghe; Fabian Y S Kong; Dedreia Tull; Karen Worthington; Marcus Y Chen; Wilhelmina M Huston; Peter Timms; Malcolm J McConville; Christopher K Fairley; Catriona S Bradshaw; Sepehr N Tabrizi; Jane S Hocking
Journal:  PLoS One       Date:  2017-05-12       Impact factor: 3.240

6.  Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men.

Authors:  Fabian Y S Kong; Thusitha W Rupasinghe; Julie A Simpson; Lenka A Vodstrcil; Christopher K Fairley; Malcolm J McConville; Jane S Hocking
Journal:  PLoS One       Date:  2017-03-28       Impact factor: 3.240
  6 in total

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