Cloning and sequencing of the murine farnesyltransferase alpha-encoding cDNA from a cell line which expresses the human papillomavirus type-16 E6 gene.

Using a differential hybridization technique, the murine farnesyltransferase alpha (FTA)-encoding cDNA was cloned from a mouse 10T1/2 cell line which expresses the human papillomavirus type 16 (HPV16) E6 gene. Sequence analysis revealed that the murine 1647-bp FTA cDNA encoded 377 amino acid (aa). The murine and human sequences showed 83.2% nucleotide and 92.6% aa sequence identity.