| Literature DB >> 7589551 |
J A McKay1, W T Melvin, A K Ah-See, S W Ewen, W F Greenlee, C B Marcus, M D Burke, G I Murray.
Abstract
The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.Entities:
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Year: 1995 PMID： 7589551 DOI： 10.1016/0014-5793(95)01126-y
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124