Literature DB >> 7589512

The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma.

M Elkin1, A Shevelev, E Schulze, M Tykocinsky, M Cooper, I Ariel, D Pode, E Kopf, N de Groot, A Hochberg.   

Abstract

The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.

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Year:  1995        PMID： 7589512     DOI： 10.1016/0014-5793(95)01074-o

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  28 in total

Review 1.  Genomic imprinting: implications for human disease.

Authors:  J G Falls; D J Pulford; A A Wylie; R L Jirtle
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

2.  The product of the imprinted H19 gene is an oncofetal RNA.

Authors:  I Ariel; S Ayesh; E J Perlman; G Pizov; V Tanos; T Schneider; V A Erdmann; D Podeh; D Komitowski; A S Quasem; N de Groot; A Hochberg
Journal:  Mol Pathol       Date:  1997-02

Review 3.  Potential applications of germline cell-derived pluripotent stem cells in organ regeneration.

Authors:  Sharmila Fagoonee; Rinaldo Pellicano; Lorenzo Silengo; Fiorella Altruda
Journal:  Organogenesis       Date:  2011-04-01       Impact factor: 2.500

4.  LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b.

Authors:  Jin Ren; Jinling Fu; Tiangang Ma; Bingdi Yan; Rong Gao; Zhe An; Dan Wang
Journal:  Cell Cycle       Date:  2018-07-23       Impact factor: 4.534

5.  Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.

Authors:  J P Issa; P M Vertino; C D Boehm; I F Newsham; S B Baylin
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

6.  Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.

Authors:  Djeda Belharazem; Julia Magdeburg; Ann-Kristin Berton; Li Beissbarth; Christian Sauer; Carsten Sticht; Alexander Marx; Ralf Hofheinz; Stefan Post; Peter Kienle; Philipp Ströbel
Journal:  J Gastroenterol       Date:  2016-03-17       Impact factor: 7.527

7.  The imprinted H19 gene is a marker of early recurrence in human bladder carcinoma.

Authors:  I Ariel; M Sughayer; Y Fellig; G Pizov; S Ayesh; D Podeh; B A Libdeh; C Levy; T Birman; M L Tykocinski; N de Groot; A Hochberg
Journal:  Mol Pathol       Date:  2000-12

8.  Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer.

Authors:  Yu-Wei Cheng; Kamran Idrees; Richard Shattock; Sajid A Khan; Zhaoshi Zeng; Cameron W Brennan; Philip Paty; Francis Barany
Journal:  Int J Cancer       Date:  2010-08-01       Impact factor: 7.396

9.  Imprinted H19 oncofetal RNA is a candidate tumour marker for hepatocellular carcinoma.

Authors:  I Ariel; H Q Miao; X R Ji; T Schneider; D Roll; N de Groot; A Hochberg; S Ayesh
Journal:  Mol Pathol       Date:  1998-02

10.  Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences.

Authors:  Aya Mizrahi; Abraham Czerniak; Tally Levy; Smadar Amiur; Jennifer Gallula; Imad Matouk; Rasha Abu-lail; Vladimir Sorin; Tatiana Birman; Nathan de Groot; Abraham Hochberg; Patricia Ohana
Journal:  J Transl Med       Date:  2009-08-06       Impact factor: 5.531
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