Literature DB >> 7589432

Cloning and sequencing of a human thioredoxin reductase.

P Y Gasdaska1, J R Gasdaska, S Cochran, G Powis.   

Abstract

The DNA sequence encoding human placental thioredoxin reductase has been determined. Of the 3826 base pairs sequenced, 1650 base pairs were in an open reading frame encoding a mature protein with 495 amino acids and a calculated molecular mass of 54,171. Sequence analysis showed strong similarity to glutathione reductases and other NADPH-dependent reductases. Human thioredoxin reductase contains the redox-active cysteines in the putative FAD binding domain and has a dimer interface domain not previously seen with prokaryote and lower eukaryote thioredoxin reductases.

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Year:  1995        PMID： 7589432     DOI： 10.1016/0014-5793(95)01003-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  37 in total

1.  Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity.

Authors:  S R Lee; S Bar-Noy; J Kwon; R L Levine; T C Stadtman; S G Rhee
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

2.  Molecular characterization and expression of Onchocerca volvulus glutathione reductase.

Authors:  S Müller; T W Gilberger; A H Fairlamb; R D Walter
Journal:  Biochem J       Date:  1997-08-01       Impact factor: 3.857

Review 3.  Thioredoxin reductase.

Authors:  D Mustacich; G Powis
Journal:  Biochem J       Date:  2000-02-15       Impact factor: 3.857

4.  Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

Authors:  V N Gladyshev; K T Jeang; T C Stadtman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

5.  Redox Equivalents and Mitochondrial Bioenergetics.

Authors:  James R Roede; Young-Mi Go; Dean P Jones
Journal:  Methods Mol Biol       Date:  2018

6.  Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence.

Authors:  L Zhong; E S Arnér; A Holmgren
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

7.  The mechanism of thioredoxin reductase from human placenta is similar to the mechanisms of lipoamide dehydrogenase and glutathione reductase and is distinct from the mechanism of thioredoxin reductase from Escherichia coli.

Authors:  L D Arscott; S Gromer; R H Schirmer; K Becker; C H Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-15       Impact factor: 11.205

8.  Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells.

Authors:  S Y Liu; T C Stadtman
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-10       Impact factor: 11.205

9.  Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.

Authors:  Marcus Conrad; Cemile Jakupoglu; Stéphanie G Moreno; Stefanie Lippl; Ana Banjac; Manuela Schneider; Heike Beck; Antonis K Hatzopoulos; Ursula Just; Fred Sinowatz; Wolfgang Schmahl; Kenneth R Chien; Wolfgang Wurst; Georg W Bornkamm; Markus Brielmeier
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

10.  Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing.

Authors:  Lingsheng Dong; Roderick V Jensen; Assunta De Rienzo; Gavin J Gordon; Yanlong Xu; David J Sugarbaker; Raphael Bueno
Journal:  BMC Med Genet       Date:  2009-12-31       Impact factor: 2.103
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