Literature DB >> 7589422

Transforming growth factor-beta 1 downregulates dexamethasone-induced tetranectin gene expression during the in vitro mineralization of the human osteoblastic cell line SV-HFO.

K Iba1, N Sawada, H Chiba, U M Wewer, S Ishii, M Mori.   

Abstract

In the present study, we examined the regulation of tetranectin gene expression using a human osteoblastic cell line, SV-HFO, that undergoes mineralization upon treatment with dexamethasone. We found that the expression of tetranectin and alkaline phosphatase mRNA was induced by dexamethasone treatment as evidenced by Northern blotting. When transforming growth factor-beta 1 (TGF-beta 1) was added together with dexamethasone to the SV-HFO cell cultures, the mineralization process was markedly suppressed and the expression of tetra nectin and alkaline phosphatase was downregulated in a dose-dependent manner. These results demonstrate that the expression of tetranectin in these osteoblastic cells is regulated by dexamethasone and TGF-beta 1 and that tetranectin expression is tightly linked to the process of mineralization.

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Year:  1995        PMID： 7589422     DOI： 10.1016/0014-5793(95)00992-i

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation.

Authors:  Daniela Lau; Dzemal Elezagic; Gabriele Hermes; Matthias Mörgelin; Alexander P Wohl; Manuel Koch; Ursula Hartmann; Stefan Höllriegl; Raimund Wagener; Mats Paulsson; Thomas Streichert; Andreas R Klatt
Journal:  J Biol Chem       Date:  2017-11-16       Impact factor: 5.157

2.  Tetranectin in slow intra- and extrafusal chicken muscle fibers.

Authors:  X Xu; B Gilpin; K Iba; A Maier; E Engvall; R Albrechtsen; U M Wewer
Journal:  J Muscle Res Cell Motil       Date:  2001       Impact factor: 2.698

3.  The heparin-binding site in tetranectin is located in the N-terminal region and binding does not involve the carbohydrate recognition domain.

Authors:  R H Lorentsen; J H Graversen; N R Caterer; H C Thogersen; M Etzerodt
Journal:  Biochem J       Date:  2000-04-01       Impact factor: 3.857

4.  Mice with a targeted deletion of the tetranectin gene exhibit a spinal deformity.

Authors:  K Iba; M E Durkin; L Johnsen; E Hunziker; K Damgaard-Pedersen; H Zhang; E Engvall; R Albrechtsen; U M Wewer
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

5.  Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs.

Authors:  Gabriela Ciapetti; Donatella Granchi; Valentina Devescovi; Serena R Baglio; Elisa Leonardi; Desirèe Martini; Maria Jesus Jurado; Beatriz Olalde; Ilaria Armentano; Josè M Kenny; Frank X Walboomers; Josè Inaki Alava; Nicola Baldini
Journal:  Int J Mol Sci       Date:  2012-02-22       Impact factor: 6.208
  5 in total

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