Literature DB >> 7588992

The identification and characterisation of chloramphenicol-aldehyde, a new human metabolite of chloramphenicol.

D E Holt1.   

Abstract

The toxic aldehyde derivative of chloramphenicol has previously been reported as a metabolic product only in the rat. Chloramphenicol-aldehyde has been synthesised and characterised and shown to exist in at least two forms, possibly due to rearrangement within the molecule. The authenticated compound has been used to identify chloramphenicol-aldehyde as a metabolic product excreted in the urine of children treated with chloramphenicol.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7588992     DOI： 10.1007/BF03192286

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  9 in total

1.  Gas chromatographic determination and gas chromatographic-mass sepectrometric analysis of chloramphenicol, thiamphenicol and their metabolites.

Authors:  T Nakagawa; M Masada; T Uno
Journal:  J Chromatogr       Date:  1975-09-03

2.  Preparation of trimethylsilyl derivates of chloramphenicol for gas-liquid chromatography.

Authors:  G Janssen; H Vanderhaeghe
Journal:  J Chromatogr       Date:  1973-08-01

Review 3.  Chloramphenicol: relation of structure to activity and toxicity.

Authors:  A A Yunis
Journal:  Annu Rev Pharmacol Toxicol       Date:  1988       Impact factor: 13.820

4.  Bone marrow toxicity in vitro of chloramphenicol and its metabolites.

Authors:  B J Gross; R V Branchflower; T R Burke; D E Lees; L R Pohl
Journal:  Toxicol Appl Pharmacol       Date:  1982-07       Impact factor: 4.219

5.  The teratogenicity of methoxyacetic acid in the rat.

Authors:  N A Brown; D Holt; M Webb
Journal:  Toxicol Lett       Date:  1984-07       Impact factor: 4.372

6.  Dimethoxyethylphthalate metabolism: teratogenicity of the diester and its metabolites in the pregnant rat.

Authors:  J Campbell; D Holt; M Webb
Journal:  J Appl Toxicol       Date:  1984-02       Impact factor: 3.446

Review 7.  Chloramphenicol toxicity.

Authors:  D Holt; D Harvey; R Hurley
Journal:  Adverse Drug React Toxicol Rev       Date:  1993

8.  Glutathione-dependent dechlorination of chloramphenicol by cytosol of rat liver.

Authors:  J L Martin; J W George; L R Pohl
Journal:  Drug Metab Dispos       Date:  1980 Mar-Apr       Impact factor: 3.922

9.  Mechanism of glutathione-dependent dechlorination of chloramphenicol and thiamphenicol by cytosol of rat liver.

Authors:  J L Martin; B J Gross; P Morris; L R Pohl
Journal:  Drug Metab Dispos       Date:  1980 Nov-Dec       Impact factor: 3.922
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.