Literature DB >> 7588988

Antenatal lung maturation--should we all be using thyrotropin-releasing hormone?

N M Fisk1, M J Peek.   

Abstract

Thyrotropin-releasing hormone (TRH) appears to be a promising antenatal therapy to help reduce neonatal lung disease. Clinical trials, however, show differing results. At present the optimum dosage, frequency and method of administration have not been established. TRH has been shown significantly to elevate blood pressure in patients with preeclampsia suggesting it should not be used in this group. Moreover concerns over its use in growth retarded fetuses and its long-term neonatal effects have not been addressed. Further trials are needed before routine clinical use can be recommended.

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Year:  1995        PMID： 7588988     DOI： 10.1007/BF02155103

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  7 in total

1.  Fetal thyroid-stimulating hormone response to maternal administration of thyrotropin-releasing hormone.

Authors:  J G Thorpe-Beeston; K H Nicolaides; R J Snijders; J Butler; A M McGregor
Journal:  Am J Obstet Gynecol       Date:  1991-05       Impact factor: 8.661

2.  Glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture.

Authors:  L W Gonzales; P L Ballard; R Ertsey; M C Williams
Journal:  J Clin Endocrinol Metab       Date:  1986-04       Impact factor: 5.958

3.  Hypertensive effect of antenatal thyrotropin-releasing hormone in pre-eclampsia.

Authors:  M J Peek; R Bajoria; A H Shennan; F Dalzell; M de Swiet; N M Fisk
Journal:  Lancet       Date:  1995-03-25       Impact factor: 79.321

4.  A randomized, controlled trial of antepartum thyrotropin-releasing hormone and betamethasone in the prevention of respiratory disease in preterm infants.

Authors:  D B Knight; G C Liggins; S R Wealthall
Journal:  Am J Obstet Gynecol       Date:  1994-07       Impact factor: 8.661

5.  Human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone.

Authors:  E Roti; A Gnudi; L E Braverman; G Robuschi; R Emanuele; P Bandini; L Benassi; A Pagliani; C H Emerson
Journal:  J Clin Endocrinol Metab       Date:  1981-10       Impact factor: 5.958

6.  Respiratory disease in very-low-birthweight infants after prenatal thyrotropin-releasing hormone and glucocorticoid. TRH Study Group.

Authors:  R A Ballard; P L Ballard; R K Creasy; J Padbury; D H Polk; M Bracken; F R Moya; I Gross
Journal:  Lancet       Date:  1992-02-29       Impact factor: 79.321

7.  Fetal lung maturation: the combined use of corticosteroids and thyrotropin-releasing hormone.

Authors:  W J Morales; W F O'Brien; J L Angel; R A Knuppel; S Sawai
Journal:  Obstet Gynecol       Date:  1989-01       Impact factor: 7.661
  7 in total

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