Literature DB >> 7588942

Upregulation of granulocyte CD11b (CR 3) after labelling with technetium-99m hexamethylpropylene amine oxime.

S Almer1, O Ljunghusen.   

Abstract

Today technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) is widely used for leucocyte scintigraphy, as 99mTc-HMPAO selectively labels granulocytes in mixed leucocyte suspensions. However, the influence of cell labelling on the expression of specific adhesion proteins has not been studied before. Therefore, we investigated five patients, four of whom had established Crohn's disease. We found that leucocyte labelling with 99mTc-HMPAO induces increased expression of the glucoprotein receptor CD11b on granulocytes, but it is not clear whether this upregulation affects the functional integrity of the granulocytes.

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Year:  1995        PMID： 7588942     DOI： 10.1007/BF00808417

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  8 in total

1.  Five leucocyte labelling techniques: a comparative in-vitro study.

Authors:  N Colas-Linhart; M Barbu; M A Gougerot; B Bok
Journal:  Br J Haematol       Date:  1983-01       Impact factor: 6.998

2.  Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.

Authors:  M B Lawrence; T A Springer
Journal:  Cell       Date:  1991-05-31       Impact factor: 41.582

3.  Do technetium-99m hexamethylpropylene amine oxime-labeled leukocytes truly reflect the mucosal inflammation in patients with ulcerative colitis?

Authors:  S Almer; L Franzén; A M Peters; M Tjädermo; S Ekberg; G Granerus; M Ström
Journal:  Scand J Gastroenterol       Date:  1992-12       Impact factor: 2.423

4.  The development of a clinical protocol for the radiolabelling of mixed leucocytes with 99Tcm-hexamethylpropyleneamine oxime.

Authors:  H J Danpure; S Osman; M J Carroll
Journal:  Nucl Med Commun       Date:  1988-06       Impact factor: 1.690

5.  Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils.

Authors:  H Sengeløv; L Kjeldsen; M S Diamond; T A Springer; N Borregaard
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808

6.  Lung transit of 111Indium-labelled granulocytes. Relationship to labelling techniques.

Authors:  S H Saverymuttu; A M Peters; H J Danpure; H J Reavy; S Osman; J P Lavender
Journal:  Scand J Haematol       Date:  1983-02

7.  Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.

Authors:  M Berger; J O'Shea; A S Cross; T M Folks; T M Chused; E J Brown; M M Frank
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

8.  ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

Authors:  M S Diamond; D E Staunton; A R de Fougerolles; S A Stacker; J Garcia-Aguilar; M L Hibbs; T A Springer
Journal:  J Cell Biol       Date:  1990-12       Impact factor: 10.539
  8 in total
  1 in total

1.  Labelling of leucocytes with technetium-99m exametazime causes in vitro upregulation of granulocyte CD11b without correlation to tissue uptake in vivo.

Authors:  S Almer; O Ljunghusen; J Lundahl
Journal:  Eur J Nucl Med       Date:  1996-06
  1 in total

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