Literature DB >> 7588437

The binding of recombinant human relaxin to human spermatozoa.

D T Carrell1, C M Peterson, R L Urry.   

Abstract

Porcine relaxin has been reported to stimulate various human sperm functions. In this paper we report that human recombinant relaxin binds to human sperm with a high affinity (Kd = 6.5 x 10(-10)). The bound 125I-relaxin was not displaced by insulin, or human chorionic gonadotropin, however, it was displaced by unlabeled relaxin. In sperm function studies, recombinant human relaxin stimulated sperm motility, zona-free hamster egg penetration, and the acrosome reaction.

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Year:  1995        PMID： 7588437     DOI： 10.1080/07435809509030484

Source DB:  PubMed          Journal:  Endocr Res        ISSN： 0743-5800            Impact factor:   1.720


  8 in total

1.  Inotropic responses to human gene 2 (B29) relaxin in a rat model of myocardial infarction (MI): effect of pertussis toxin.

Authors:  Andrew R Kompa; Chrishan S Samuel; Roger J Summers
Journal:  Br J Pharmacol       Date:  2002-11       Impact factor: 8.739

Review 2.  International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

Authors:  Michelle L Halls; Ross A D Bathgate; Steve W Sutton; Thomas B Dschietzig; Roger J Summers
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

3.  Effects of relaxin and IGF-I on capacitation, acrosome reaction, cholesterol efflux and utilization of labeled and unlabeled glucose in porcine spermatozoa.

Authors:  Abdul Gaffar Miah; Ummay Salma; Yuji Takagi; Tetsuya Kohsaka; Ko-Ichi Hamano; Hirotada Tsujii
Journal:  Reprod Med Biol       Date:  2008-02-01

Review 4.  Activation of motility and chemotaxis in the spermatozoa: From invertebrates to humans.

Authors:  Masaaki Morisawa; Manabu Yoshida
Journal:  Reprod Med Biol       Date:  2005-05-03

5.  Beneficial effects of relaxin on motility characteristics of stored boar spermatozoa.

Authors:  Jean M Feugang; Juan C Rodríguez-Muñoz; Darby S Dillard; Mark A Crenshaw; Scott T Willard; Peter L Ryan
Journal:  Reprod Biol Endocrinol       Date:  2015-03-31       Impact factor: 5.211

6.  Relaxin family peptide receptors Rxfp1 and Rxfp2: mapping of the mRNA and protein distribution in the reproductive tract of the male rat.

Authors:  Marcelo Filonzi; Laís C Cardoso; Maristela T Pimenta; Daniel B C Queiróz; Maria C W Avellar; Catarina S Porto; Maria F M Lazari
Journal:  Reprod Biol Endocrinol       Date:  2007-07-10       Impact factor: 5.211

Review 7.  Biology of primate relaxin: a paracrine signal in early pregnancy?

Authors:  Eric S Hayes
Journal:  Reprod Biol Endocrinol       Date:  2004-06-16       Impact factor: 5.211

8.  Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus.

Authors:  Danielle J Glynn; Kee Heng; Darryl L Russell; David J Sharkey; Sarah A Robertson; Ravinder Anand-Ivell; Richard Ivell
Journal:  Front Physiol       Date:  2017-06-19       Impact factor: 4.566
  8 in total

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