Literature DB >> 7585922

Neuropeptides in the cerebral circulation: relevance to headache.

L Edvinsson1, P J Goadsby.   

Abstract

The article briefly describe the innervation of the human cerebral circulation by nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), substance P (SP), and calcitonin gene-related peptide (CGRP). The neuropeptides in human cerebral arteries were characterized by radioimmunoassay in combination with HPLC. These neuropeptides mediate contraction (NPY) and dilation (VIP, SP, CGRP). In conjunction with spontaneous attacks of migraine or cluster headache, release of CGRP is seen. With the associated symptoms of nasal congestion and rhinorrhea, VIP is released. Successful treatment may abort the peptide release in parallel with disappearance of headache.

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Year:  1995        PMID： 7585922     DOI： 10.1046/j.1468-2982.1995.1504272.x

Source DB:  PubMed          Journal:  Cephalalgia        ISSN： 0333-1024            Impact factor:   6.292


  26 in total

1.  Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.

Authors:  Thomas Denekas; Markus Tröltzsch; Axel Vater; Sven Klussmann; Karl Messlinger
Journal:  Br J Pharmacol       Date:  2006-04-24       Impact factor: 8.739

Review 2.  [Neuropeptide effects on the trigeminal system: pathophysiology and clinical significance for migraine].

Authors:  K Messlinger; M J M Fischer; J K Lennerz
Journal:  Schmerz       Date:  2011-08       Impact factor: 1.107

Review 3.  Where does a migraine attack originate? In the brainstem.

Authors:  J Tajti; D Szok; Á Párdutz; B Tuka; A Csáti; A Kuris; J Toldi; L Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2012-03-18       Impact factor: 3.575

4.  [Pathophysiological role of calcitonin gene-related peptide (CGRP) in migraine and cluster headache].

Authors:  Karl Meßlinger
Journal:  Schmerz       Date:  2020-04       Impact factor: 1.107

5.  The association between calcitonin gene-related peptide (CGRP), substance P and headache in pituitary tumours.

Authors:  M J Levy; J D Classey; S Maneesri; K Meeran; M Powell; P J Goadsby
Journal:  Pituitary       Date:  2004       Impact factor: 4.107

6.  Triptan-induced latent sensitization: a possible basis for medication overuse headache.

Authors:  Milena De Felice; Michael H Ossipov; Ruizhong Wang; Josephine Lai; Juliana Chichorro; Ian Meng; David W Dodick; Todd W Vanderah; Gregory Dussor; Frank Porreca
Journal:  Ann Neurol       Date:  2010-03       Impact factor: 10.422

7.  Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.

Authors:  A A Parsons; S Bingham; P Raval; S Read; M Thompson; N Upton
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

Review 8.  Migraine is a neuronal disease.

Authors:  J Tajti; A Párdutz; E Vámos; B Tuka; A Kuris; Zs Bohár; A Fejes; J Toldi; L Vécsei
Journal:  J Neural Transm (Vienna)       Date:  2010-12-15       Impact factor: 3.575

Review 9.  A practical guide to the management and prevention of migraine.

Authors:  H C Diener; H Kaube; V Limmroth
Journal:  Drugs       Date:  1998-11       Impact factor: 9.546

Review 10.  [Pathophysiology of migraine and clinical implications].

Authors:  M Schürks; H-C Diener
Journal:  Schmerz       Date:  2008-10       Impact factor: 1.107
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