| Literature DB >> 7585606 |
S M Hewitt1, S Hamada, T J McDonnell, F J Rauscher, G F Saunders.
Abstract
The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regulation of apoptosis and cell proliferation with roles in development and oncogenesis. We found that WT1 can repress transcription of both the bcl-2 and c-myc promoters. This suggests that WT1 regulates bcl-2 and c-myc during renal development, and the loss of functional WT1 results in deregulation of bcl-2 and c-myc, contributing to tumor formation.Entities:
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Year: 1995 PMID： 7585606
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701